SiRNA conjugate delivery systems

Ji Hoon Jeong, Hyejung Mok, Yu Kyoung Oh, Tae Gwan Park

Research output: Contribution to journalReview articlepeer-review

300 Scopus citations

Abstract

Small interfering RNA (siRNA) has been chemically conjugated to a variety of bioactive molecules, lipids, polymers, peptides, and inorganic nanostructured materials to enhance their pharmacokinetic behavior, cellular uptake, target specificity, and safety. To efficiently deliver siRNAs to the target cells and tissues, many different siRNA bioconjugates were synthesized and characterized, and their gene silencing efficiencies were tested in vitro and in vivo. In this review, recent developments of siRNA bioconjugates are summarized.

Original languageEnglish
Pages (from-to)5-14
Number of pages10
JournalBioconjugate Chemistry
Volume20
Issue number1
DOIs
StatePublished - Jan 2009
Externally publishedYes

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