Single-molecule fluorescence and force microscopy employing carbon nanotubes

Lawrence A. Wade; Ian Shapiro; Ziyang Ma; Stephen R. Quake; Charles Patrick Collier

Single-molecule fluorescence and force microscopy employing carbon nanotubes

Lawrence A. Wade, Ian Shapiro, Ziyang Ma, Stephen R. Quake, Charles Patrick Collier

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

3 Scopus citations

Abstract

We are developing generalized high-throughput techniques for the growth and attachment of single-wall nanotubes (SWNTs) as robust and well-characterized tools for AFM imaging, to serve as the foundation of an effort to develop single-molecule sensors on nanotube AFM tips for a hybrid atomic force microscope that also has single-molecule fluorescence imaging capability. We have been most successful in attaching SWNTs to AFM tips by growing individual SWNTs on flat surfaces, and using the silicon probe tip to pick up vertically oriented tubes during imaging of these substrates in tapping mode. Once a nanotube has been picked up and shortened, the probe can be transferred to a sample for high-resolution imaging, biomolecular manipulations or force spectroscopy. SWNT AFM images can be used to determine the equivalent resolution to be typically <4 nm for 3 nm diameter SWNTs (noise floor width - tube diameter). This is a factor of two better than is normally achieved with the best conventional silicon tips.

Original language	English
Title of host publication	2003 Nanotechnology Conference and Trade Show - Nanotech 2003
Editors	M. Laudon, B. Romanowicz
Pages	317-320
Number of pages	4
State	Published - 2003
Externally published	Yes
Event	2003 Nanotechnology Conference and Trade Show - Nanotech 2003 - San Francisco, CA, United States Duration: Feb 23 2003 → Feb 27 2003

Publication series

Name	2003 Nanotechnology Conference and Trade Show - Nanotech 2003
Volume	3

Conference

Conference	2003 Nanotechnology Conference and Trade Show - Nanotech 2003
Country/Territory	United States
City	San Francisco, CA
Period	02/23/03 → 02/27/03

Keywords

Nanotube AFM imaging
Nanotube AFM tip
Nanotube growth
Nanotube tip
Nanotubes

Cite this

@inproceedings{36da2c73e8e84e5684e11f5602a872b3,

title = "Single-molecule fluorescence and force microscopy employing carbon nanotubes",

abstract = "We are developing generalized high-throughput techniques for the growth and attachment of single-wall nanotubes (SWNTs) as robust and well-characterized tools for AFM imaging, to serve as the foundation of an effort to develop single-molecule sensors on nanotube AFM tips for a hybrid atomic force microscope that also has single-molecule fluorescence imaging capability. We have been most successful in attaching SWNTs to AFM tips by growing individual SWNTs on flat surfaces, and using the silicon probe tip to pick up vertically oriented tubes during imaging of these substrates in tapping mode. Once a nanotube has been picked up and shortened, the probe can be transferred to a sample for high-resolution imaging, biomolecular manipulations or force spectroscopy. SWNT AFM images can be used to determine the equivalent resolution to be typically <4 nm for 3 nm diameter SWNTs (noise floor width - tube diameter). This is a factor of two better than is normally achieved with the best conventional silicon tips.",

keywords = "Nanotube AFM imaging, Nanotube AFM tip, Nanotube growth, Nanotube tip, Nanotubes",

author = "Wade, {Lawrence A.} and Ian Shapiro and Ziyang Ma and Quake, {Stephen R.} and Collier, {Charles Patrick}",

year = "2003",

language = "English",

isbn = "0972842209",

series = "2003 Nanotechnology Conference and Trade Show - Nanotech 2003",

pages = "317--320",

editor = "M. Laudon and B. Romanowicz",

booktitle = "2003 Nanotechnology Conference and Trade Show - Nanotech 2003",

note = "2003 Nanotechnology Conference and Trade Show - Nanotech 2003 ; Conference date: 23-02-2003 Through 27-02-2003",

}

Wade, LA, Shapiro, I, Ma, Z, Quake, SR & Collier, CP 2003, Single-molecule fluorescence and force microscopy employing carbon nanotubes. in M Laudon & B Romanowicz (eds), 2003 Nanotechnology Conference and Trade Show - Nanotech 2003. 2003 Nanotechnology Conference and Trade Show - Nanotech 2003, vol. 3, pp. 317-320, 2003 Nanotechnology Conference and Trade Show - Nanotech 2003, San Francisco, CA, United States, 02/23/03.

Single-molecule fluorescence and force microscopy employing carbon nanotubes. / Wade, Lawrence A.; Shapiro, Ian; Ma, Ziyang et al.
2003 Nanotechnology Conference and Trade Show - Nanotech 2003. ed. / M. Laudon; B. Romanowicz. 2003. p. 317-320 (2003 Nanotechnology Conference and Trade Show - Nanotech 2003; Vol. 3).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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AU - Shapiro, Ian

AU - Ma, Ziyang

AU - Quake, Stephen R.

AU - Collier, Charles Patrick

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N2 - We are developing generalized high-throughput techniques for the growth and attachment of single-wall nanotubes (SWNTs) as robust and well-characterized tools for AFM imaging, to serve as the foundation of an effort to develop single-molecule sensors on nanotube AFM tips for a hybrid atomic force microscope that also has single-molecule fluorescence imaging capability. We have been most successful in attaching SWNTs to AFM tips by growing individual SWNTs on flat surfaces, and using the silicon probe tip to pick up vertically oriented tubes during imaging of these substrates in tapping mode. Once a nanotube has been picked up and shortened, the probe can be transferred to a sample for high-resolution imaging, biomolecular manipulations or force spectroscopy. SWNT AFM images can be used to determine the equivalent resolution to be typically <4 nm for 3 nm diameter SWNTs (noise floor width - tube diameter). This is a factor of two better than is normally achieved with the best conventional silicon tips.

AB - We are developing generalized high-throughput techniques for the growth and attachment of single-wall nanotubes (SWNTs) as robust and well-characterized tools for AFM imaging, to serve as the foundation of an effort to develop single-molecule sensors on nanotube AFM tips for a hybrid atomic force microscope that also has single-molecule fluorescence imaging capability. We have been most successful in attaching SWNTs to AFM tips by growing individual SWNTs on flat surfaces, and using the silicon probe tip to pick up vertically oriented tubes during imaging of these substrates in tapping mode. Once a nanotube has been picked up and shortened, the probe can be transferred to a sample for high-resolution imaging, biomolecular manipulations or force spectroscopy. SWNT AFM images can be used to determine the equivalent resolution to be typically <4 nm for 3 nm diameter SWNTs (noise floor width - tube diameter). This is a factor of two better than is normally achieved with the best conventional silicon tips.

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T3 - 2003 Nanotechnology Conference and Trade Show - Nanotech 2003

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BT - 2003 Nanotechnology Conference and Trade Show - Nanotech 2003

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ER -

Single-molecule fluorescence and force microscopy employing carbon nanotubes

Abstract

Publication series

Conference

Keywords

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