Separation of ¹⁰³Ru from a proton irradiated thorium matrix: A potential source of Auger therapy radionuclide^103mRh

Ruthenium-103 is the parent isotope of ^103mRh (t_1/2 56.1 min), an isotope of interest for Auger electron therapy. During the proton irradiation of thorium targets, large amounts of ¹⁰³Ru are generated through proton induced fission. The development of a two part chemical separation process to isolate ¹⁰³Ru in high yield and purity from a proton irradiated thorium matrix on an analytical scale is described herein. The first part employed an anion exchange column to remove cationic actinide/lanthanide impurities along with the majority of the transition metal fission products. Secondly, an extraction chromatographic column utilizing diglycolamide functional groups was used to decontaminate ¹⁰³Ru from the remaining impurities. This method resulted in a final radiochemical yield of 83 ± 5% of ¹⁰³Ru with a purity of 99.9%. Additionally, measured nuclear reaction cross sections for the formation of ¹⁰³Ru and ¹⁰⁶Ru via the ²³²Th(p,f)^103,106Ru reactions are reported within.