Sensing DNA hybridization via ionic conductance through a nanoporous electrode

Ivan Vlassiouk; Pavel Takmakov; Sergei Smirnov

doi:10.1021/la0471644

Sensing DNA hybridization via ionic conductance through a nanoporous electrode

Ivan Vlassiouk
, Pavel Takmakov
, Sergei Smirnov

Research output: Contribution to journal › Article › peer-review

122 Scopus citations

Abstract

We show that nanoporous alumina modified with covalently linked DNA can be used to detect target DNA by monitoring the increase in impedance at the electrode upon DNA hybridization, which resulted from blocking the pores to ionic flow. Using cyclic voltammetry, direct current conductance, and impedance spectroscopy we confirm the importance of pore size: the effect is observed with 20-nm-diameter pores and is absent for 200-nm pores.

Original language	English
Pages (from-to)	4776-4778
Number of pages	3
Journal	Langmuir
Volume	21
Issue number	11
DOIs	https://doi.org/10.1021/la0471644
State	Published - May 24 2005
Externally published	Yes

Access to Document

10.1021/la0471644

Cite this

@article{33fe4caa1d9d40ec8e1db6d2391462b2,

title = "Sensing DNA hybridization via ionic conductance through a nanoporous electrode",

abstract = "We show that nanoporous alumina modified with covalently linked DNA can be used to detect target DNA by monitoring the increase in impedance at the electrode upon DNA hybridization, which resulted from blocking the pores to ionic flow. Using cyclic voltammetry, direct current conductance, and impedance spectroscopy we confirm the importance of pore size: the effect is observed with 20-nm-diameter pores and is absent for 200-nm pores.",

author = "Ivan Vlassiouk and Pavel Takmakov and Sergei Smirnov",

year = "2005",

month = may,

day = "24",

doi = "10.1021/la0471644",

language = "English",

volume = "21",

pages = "4776--4778",

journal = "Langmuir",

issn = "0743-7463",

publisher = "American Chemical Society",

number = "11",

}

TY - JOUR

T1 - Sensing DNA hybridization via ionic conductance through a nanoporous electrode

AU - Vlassiouk, Ivan

AU - Takmakov, Pavel

AU - Smirnov, Sergei

PY - 2005/5/24

Y1 - 2005/5/24

N2 - We show that nanoporous alumina modified with covalently linked DNA can be used to detect target DNA by monitoring the increase in impedance at the electrode upon DNA hybridization, which resulted from blocking the pores to ionic flow. Using cyclic voltammetry, direct current conductance, and impedance spectroscopy we confirm the importance of pore size: the effect is observed with 20-nm-diameter pores and is absent for 200-nm pores.

AB - We show that nanoporous alumina modified with covalently linked DNA can be used to detect target DNA by monitoring the increase in impedance at the electrode upon DNA hybridization, which resulted from blocking the pores to ionic flow. Using cyclic voltammetry, direct current conductance, and impedance spectroscopy we confirm the importance of pore size: the effect is observed with 20-nm-diameter pores and is absent for 200-nm pores.

UR - https://www.scopus.com/pages/publications/20444414510

U2 - 10.1021/la0471644

DO - 10.1021/la0471644

M3 - Article

C2 - 15896007

AN - SCOPUS:20444414510

SN - 0743-7463

VL - 21

SP - 4776

EP - 4778

JO - Langmuir

JF - Langmuir

IS - 11

ER -

Sensing DNA hybridization via ionic conductance through a nanoporous electrode

Abstract

Access to Document

Other files and links

Fingerprint

Cite this