Self-assembled and nanostructured siRNA delivery systems

Ji Hoon Jeong; Tae Gwan Park; Sun Hwa Kim

doi:10.1007/s11095-011-0412-y

Self-assembled and nanostructured siRNA delivery systems

Ji Hoon Jeong, Tae Gwan Park, Sun Hwa Kim

Research output: Contribution to journal › Review article › peer-review

53 Scopus citations

Abstract

A wide range of organic and inorganic materials have been used in the development of nano-scale selfassembling gene delivery systems to improve the therapeutic efficacy of nucleic acid drugs. Small interfering RNA (siRNA) has recently been recognized as a promising and potent nucleic acid medicine for the treatment of incurable genetic disorders including cancer; however, siRNA-based therapeutics suffer from the same delivery problems as conventional nucleic acid drugs such as plasmid DNA and antisense oligonucleotides. Many of the delivery strategies developed for nucleic acid drugs have been applied to siRNA therapeutics, but they have not produced satisfactory in vivo gene silencing efficiencies to warrant clinical trials. This review discusses recent progress in the development of self-assembled and nanostructured delivery systems for efficient siRNA-induced gene silencing and their potential application in clinical settings.

Original language	English
Pages (from-to)	2072-2085
Number of pages	14
Journal	Pharmaceutical Research: An Official Journal of the American Association of Pharmaceutical Scientists
Volume	28
Issue number	9
DOIs	https://doi.org/10.1007/s11095-011-0412-y
State	Published - Sep 2011
Externally published	Yes

Funding

This study was supported by the Korea Healthcare Technology R&D Project from the Ministry for Health, Welfare & Family Affairs (A085136), Basic Science Research Program through the National Research Foundation of Korea funded by the Ministry of Education, Science and Technology (2010–0022471), National Research Laboratory Basic Science Research Program (2010–0027955), and WCU Program from the Ministry of Education, and Science and Technology, Republic of Korea.

Funders	Funder number
Ministry of Education, and Science and Technology, Republic of Korea
National Research Laboratory Basic Science Research Program	2010–0027955
Ministry of Health and Welfare	A085136
National Research Foundation of Korea
Ministry of Education, Science and Technology	2010–0022471

Keywords

Non-viral gene carriers
PEGylated polyplex
Self-assembled nanostructures
siRNA medicines
siRNA-PEG conjugates

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1007/s11095-011-0412-y

Cite this

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AB - A wide range of organic and inorganic materials have been used in the development of nano-scale selfassembling gene delivery systems to improve the therapeutic efficacy of nucleic acid drugs. Small interfering RNA (siRNA) has recently been recognized as a promising and potent nucleic acid medicine for the treatment of incurable genetic disorders including cancer; however, siRNA-based therapeutics suffer from the same delivery problems as conventional nucleic acid drugs such as plasmid DNA and antisense oligonucleotides. Many of the delivery strategies developed for nucleic acid drugs have been applied to siRNA therapeutics, but they have not produced satisfactory in vivo gene silencing efficiencies to warrant clinical trials. This review discusses recent progress in the development of self-assembled and nanostructured delivery systems for efficient siRNA-induced gene silencing and their potential application in clinical settings.

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KW - Self-assembled nanostructures

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Self-assembled and nanostructured siRNA delivery systems

Abstract

Funding

Keywords

UN SDGs

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