Seeing through Walls at the Nanoscale: Microwave Microscopy of Enclosed Objects and Processes in Liquids

Alexander Tselev; Jeyavel Velmurugan; Anton V. Ievlev; Sergei V. Kalinin; Andrei Kolmakov

doi:10.1021/acsnano.5b07919

Seeing through Walls at the Nanoscale: Microwave Microscopy of Enclosed Objects and Processes in Liquids

Alexander Tselev, Jeyavel Velmurugan, Anton V. Ievlev, Sergei V. Kalinin, Andrei Kolmakov

Functional Atomic Force Microscopy Group

Research output: Contribution to journal › Article › peer-review

47 Scopus citations

Abstract

Noninvasive in situ nanoscale imaging in liquid environments is a current imperative in the analysis of delicate biomedical objects and electrochemical processes at reactive liquid-solid interfaces. Microwaves of a few gigahertz frequencies offer photons with energies of ≈10 μeV, which can affect neither electronic states nor chemical bonds in condensed matter. Here, we describe an implementation of scanning near-field microwave microscopy for imaging in liquids using ultrathin molecular impermeable membranes separating scanning probes from samples enclosed in environmental cells. We imaged a model electroplating reaction as well as individual live cells. Through a side-by-side comparison of the microwave imaging with scanning electron microscopy, we demonstrate the advantage of microwaves for artifact-free imaging.

Original language	English
Pages (from-to)	3562-3570
Number of pages	9
Journal	ACS Nano
Volume	10
Issue number	3
DOIs	https://doi.org/10.1021/acsnano.5b07919
State	Published - Mar 22 2016

Funding

Microwave imaging was conducted at the Center for Nanoscale Science and Technology, NIST, and at the Center for Nanophase Materials Sciences, ORNL, which also provided support (A.T., A.V.I., S.V.K.) and which is sponsored at Oak Ridge National Laboratory by the Scientific User Facilities Division, Office of Basic Energy Sciences, U.S. Department of Energy. A.T. acknowledges support by U.S. Civilian Research and Development Foundation. J.V. work was supported by a NIST-CNST/UMD-IREAP Cooperative Agreement. Authors are thankful to Dr. K. Siebein for the experimental support, and to Dr. T. Moffat, Dr. M. Stiles, and Dr. N. Zhitenev (all at NIST) for their valuable discussions.

Funders	Funder number
Center for Nanophase Materials Sciences
Scientific User Facilities Division
U.S. Department of Energy
National Institute of Standards and Technology
CRDF Global
Basic Energy Sciences
Oak Ridge National Laboratory

Keywords

encapsulation
in situ imaging
near-field microwave microscopy
radiolysis-free in-liquid imaging

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10.1021/acsnano.5b07919

Cite this

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abstract = "Noninvasive in situ nanoscale imaging in liquid environments is a current imperative in the analysis of delicate biomedical objects and electrochemical processes at reactive liquid-solid interfaces. Microwaves of a few gigahertz frequencies offer photons with energies of ≈10 μeV, which can affect neither electronic states nor chemical bonds in condensed matter. Here, we describe an implementation of scanning near-field microwave microscopy for imaging in liquids using ultrathin molecular impermeable membranes separating scanning probes from samples enclosed in environmental cells. We imaged a model electroplating reaction as well as individual live cells. Through a side-by-side comparison of the microwave imaging with scanning electron microscopy, we demonstrate the advantage of microwaves for artifact-free imaging.",

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AB - Noninvasive in situ nanoscale imaging in liquid environments is a current imperative in the analysis of delicate biomedical objects and electrochemical processes at reactive liquid-solid interfaces. Microwaves of a few gigahertz frequencies offer photons with energies of ≈10 μeV, which can affect neither electronic states nor chemical bonds in condensed matter. Here, we describe an implementation of scanning near-field microwave microscopy for imaging in liquids using ultrathin molecular impermeable membranes separating scanning probes from samples enclosed in environmental cells. We imaged a model electroplating reaction as well as individual live cells. Through a side-by-side comparison of the microwave imaging with scanning electron microscopy, we demonstrate the advantage of microwaves for artifact-free imaging.

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Seeing through Walls at the Nanoscale: Microwave Microscopy of Enclosed Objects and Processes in Liquids

Abstract

Funding

Keywords

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