SANS study on the effect of lanthanide ions and charged lipids on the morphology of phospholipid mixtures

Mu Ping Nieh; Charles J. Glinka; Susan Krueger; R. Scott Prosser; John Katsaras

doi:10.1016/S0006-3495(02)75591-4

SANS study on the effect of lanthanide ions and charged lipids on the morphology of phospholipid mixtures

Mu Ping Nieh
, Charles J. Glinka
, Susan Krueger
, R. Scott Prosser
, John Katsaras

Research output: Contribution to journal › Article › peer-review

138 Scopus citations

Abstract

The structural phase behavior of phospholipid mixtures consisting of short-chain (dihexanoyl phosphatidylcholine) and long-chain lipids (dimyristoyl phosphatidylcholine and dimyristoyl phosphatidylglycerol), with and without lanthanide ions was investigated by small-angle neutron scattering (SANS). SANS profiles were obtained from 10°C to 55°C using lipid concentrations ranging from 0.0025 g/mi to 0.25 g/mi. The results reveal a wealth of distinct morphologies, including lamellae, multi-lamellar vesicles, unilamellar vesicles, and bicellar disks.

Original language	English
Pages (from-to)	2487-2498
Number of pages	12
Journal	Biophysical Journal
Volume	82
Issue number	5
DOIs	https://doi.org/10.1016/S0006-3495(02)75591-4
State	Published - 2002
Externally published	Yes

Funding

This work is based upon activities supported by the National Science Foundation under agreement DMR 9986442.

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10.1016/S0006-3495(02)75591-4

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title = "SANS study on the effect of lanthanide ions and charged lipids on the morphology of phospholipid mixtures",

abstract = "The structural phase behavior of phospholipid mixtures consisting of short-chain (dihexanoyl phosphatidylcholine) and long-chain lipids (dimyristoyl phosphatidylcholine and dimyristoyl phosphatidylglycerol), with and without lanthanide ions was investigated by small-angle neutron scattering (SANS). SANS profiles were obtained from 10°C to 55°C using lipid concentrations ranging from 0.0025 g/mi to 0.25 g/mi. The results reveal a wealth of distinct morphologies, including lamellae, multi-lamellar vesicles, unilamellar vesicles, and bicellar disks.",

author = "Nieh, \{Mu Ping\} and Glinka, \{Charles J.\} and Susan Krueger and \{Scott Prosser\}, R. and John Katsaras",

year = "2002",

doi = "10.1016/S0006-3495(02)75591-4",

language = "English",

volume = "82",

pages = "2487--2498",

journal = "Biophysical Journal",

issn = "0006-3495",

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T1 - SANS study on the effect of lanthanide ions and charged lipids on the morphology of phospholipid mixtures

AU - Nieh, Mu Ping

AU - Glinka, Charles J.

AU - Krueger, Susan

AU - Scott Prosser, R.

AU - Katsaras, John

PY - 2002

Y1 - 2002

N2 - The structural phase behavior of phospholipid mixtures consisting of short-chain (dihexanoyl phosphatidylcholine) and long-chain lipids (dimyristoyl phosphatidylcholine and dimyristoyl phosphatidylglycerol), with and without lanthanide ions was investigated by small-angle neutron scattering (SANS). SANS profiles were obtained from 10°C to 55°C using lipid concentrations ranging from 0.0025 g/mi to 0.25 g/mi. The results reveal a wealth of distinct morphologies, including lamellae, multi-lamellar vesicles, unilamellar vesicles, and bicellar disks.

AB - The structural phase behavior of phospholipid mixtures consisting of short-chain (dihexanoyl phosphatidylcholine) and long-chain lipids (dimyristoyl phosphatidylcholine and dimyristoyl phosphatidylglycerol), with and without lanthanide ions was investigated by small-angle neutron scattering (SANS). SANS profiles were obtained from 10°C to 55°C using lipid concentrations ranging from 0.0025 g/mi to 0.25 g/mi. The results reveal a wealth of distinct morphologies, including lamellae, multi-lamellar vesicles, unilamellar vesicles, and bicellar disks.

UR - https://www.scopus.com/pages/publications/0036229930

U2 - 10.1016/S0006-3495(02)75591-4

DO - 10.1016/S0006-3495(02)75591-4

M3 - Article

C2 - 11964236

AN - SCOPUS:0036229930

SN - 0006-3495

VL - 82

SP - 2487

EP - 2498

JO - Biophysical Journal

JF - Biophysical Journal

IS - 5

ER -

SANS study on the effect of lanthanide ions and charged lipids on the morphology of phospholipid mixtures

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