SANS study on the effect of lanthanide ions and charged lipids on the morphology of phospholipid mixtures

Mu Ping Nieh; Charles J. Glinka; Susan Krueger; R. Scott Prosser; John Katsaras

doi:10.1016/S0006-3495(02)75591-4

SANS study on the effect of lanthanide ions and charged lipids on the morphology of phospholipid mixtures

Mu Ping Nieh, Charles J. Glinka, Susan Krueger, R. Scott Prosser, John Katsaras

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134 Scopus citations

Abstract

The structural phase behavior of phospholipid mixtures consisting of short-chain (dihexanoyl phosphatidylcholine) and long-chain lipids (dimyristoyl phosphatidylcholine and dimyristoyl phosphatidylglycerol), with and without lanthanide ions was investigated by small-angle neutron scattering (SANS). SANS profiles were obtained from 10°C to 55°C using lipid concentrations ranging from 0.0025 g/mi to 0.25 g/mi. The results reveal a wealth of distinct morphologies, including lamellae, multi-lamellar vesicles, unilamellar vesicles, and bicellar disks.

Original language	English
Pages (from-to)	2487-2498
Number of pages	12
Journal	Biophysical Journal
Volume	82
Issue number	5
DOIs	https://doi.org/10.1016/S0006-3495(02)75591-4
State	Published - 2002
Externally published	Yes

Funding

This work is based upon activities supported by the National Science Foundation under agreement DMR 9986442.

Funders	Funder number
National Science Foundation	DMR 9986442
Directorate for Mathematical and Physical Sciences	9986442

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10.1016/S0006-3495(02)75591-4

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title = "SANS study on the effect of lanthanide ions and charged lipids on the morphology of phospholipid mixtures",

abstract = "The structural phase behavior of phospholipid mixtures consisting of short-chain (dihexanoyl phosphatidylcholine) and long-chain lipids (dimyristoyl phosphatidylcholine and dimyristoyl phosphatidylglycerol), with and without lanthanide ions was investigated by small-angle neutron scattering (SANS). SANS profiles were obtained from 10°C to 55°C using lipid concentrations ranging from 0.0025 g/mi to 0.25 g/mi. The results reveal a wealth of distinct morphologies, including lamellae, multi-lamellar vesicles, unilamellar vesicles, and bicellar disks.",

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T1 - SANS study on the effect of lanthanide ions and charged lipids on the morphology of phospholipid mixtures

AU - Nieh, Mu Ping

AU - Glinka, Charles J.

AU - Krueger, Susan

AU - Scott Prosser, R.

AU - Katsaras, John

PY - 2002

Y1 - 2002

N2 - The structural phase behavior of phospholipid mixtures consisting of short-chain (dihexanoyl phosphatidylcholine) and long-chain lipids (dimyristoyl phosphatidylcholine and dimyristoyl phosphatidylglycerol), with and without lanthanide ions was investigated by small-angle neutron scattering (SANS). SANS profiles were obtained from 10°C to 55°C using lipid concentrations ranging from 0.0025 g/mi to 0.25 g/mi. The results reveal a wealth of distinct morphologies, including lamellae, multi-lamellar vesicles, unilamellar vesicles, and bicellar disks.

AB - The structural phase behavior of phospholipid mixtures consisting of short-chain (dihexanoyl phosphatidylcholine) and long-chain lipids (dimyristoyl phosphatidylcholine and dimyristoyl phosphatidylglycerol), with and without lanthanide ions was investigated by small-angle neutron scattering (SANS). SANS profiles were obtained from 10°C to 55°C using lipid concentrations ranging from 0.0025 g/mi to 0.25 g/mi. The results reveal a wealth of distinct morphologies, including lamellae, multi-lamellar vesicles, unilamellar vesicles, and bicellar disks.

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SN - 0006-3495

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SP - 2487

EP - 2498

JO - Biophysical Journal

JF - Biophysical Journal

IS - 5

ER -

SANS study on the effect of lanthanide ions and charged lipids on the morphology of phospholipid mixtures

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