@article{e27c5e290c9448f39fb1bf79aed989ba,
title = "Salt-Induced Universal Slowing Down of the Short-Time Self-Diffusion of a Globular Protein in Aqueous Solution",
abstract = "The short-time self-diffusion D of the globular model protein bovine serum albumin in aqueous (D2O) solutions has been measured comprehensively as a function of the protein and trivalent salt (YCl3) concentration, noted cp and cs, respectively. We observe that D follows a universal master curve D(cs,cp) = D(cs = 0,cp) g(cs/cp), where D(cs = 0,cp) is the diffusion coefficient in the absence of salt and g(cs/cp) is a scalar function solely depending on the ratio of the salt and protein concentration. This observation is consistent with a universal scaling of the bonding probability in a picture of cluster formation of patchy particles. The finding corroborates the predictive power of the description of proteins as colloids with distinct attractive ion-activated surface patches.",
keywords = "{"}patchy{"} colloids, cluster formation, neutron spectroscopy, protein dynamics, self-assembly",
author = "Marco Grimaldo and Felix Roosen-Runge and Marcus Hennig and Fabio Zanini and Fajun Zhang and Michaela Zamponi and Niina Jalarvo and Frank Schreiber and Tilo Seydel",
note = "Publisher Copyright: {\textcopyright} 2015 American Chemical Society.",
year = "2015",
month = jun,
day = "19",
doi = "10.1021/acs.jpclett.5b01073",
language = "English",
volume = "6",
pages = "2577--2582",
journal = "Journal of Physical Chemistry Letters",
issn = "1948-7185",
publisher = "American Chemical Society",
number = "13",
}