Abstract
In this chapter, we highlight the recent progress in the synthesis of well-defined polymers that self-assemble into micelles in aqueous solutions, and which have been loaded with anticancer drugs and studied for their functionality. Initially, we describe the synthesis of pH-responsive polymeric materials, and their study through in vitro and in vivo tests. Then we report the thermo-, redox-, magnetic-responsive micelle carrying anticancer agents. Finally, we present the multiresponsive and the nanocarriers bearing surface markers to target cancer cells. A short description has been given for the biological results of these nanocarriers. In this chapter, we cover all the main stimuli-responsive functionalities of the most recent literature.
Original language | English |
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Title of host publication | Stimuli Responsive Polymeric Nanocarriers for Drug Delivery Applications |
Subtitle of host publication | Volume 2: Advanced Nanocarriers for Therapeutics |
Publisher | Elsevier |
Pages | 439-460 |
Number of pages | 22 |
ISBN (Electronic) | 9780081019955 |
ISBN (Print) | 9780081019962 |
DOIs | |
State | Published - Jan 1 2018 |
Externally published | Yes |
Keywords
- Anticancer drugs
- Cancer
- Drug delivery
- In vitro
- In vivo
- Micelles
- Polymeric nanocarriers
- Polypeptides
- Stimuli-responsive