Responsive polymeric micelles for drug delivery applications/cancer therapy

Panagiota G. Fragouli, Dimitra Stavroulaki, Panagiotis Christakopoulos, Varvara Athanasiou, Maria Kasimati, Katerina Mathianaki, Hermis Iatrou

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

2 Scopus citations

Abstract

In this chapter, we highlight the recent progress in the synthesis of well-defined polymers that self-assemble into micelles in aqueous solutions, and which have been loaded with anticancer drugs and studied for their functionality. Initially, we describe the synthesis of pH-responsive polymeric materials, and their study through in vitro and in vivo tests. Then we report the thermo-, redox-, magnetic-responsive micelle carrying anticancer agents. Finally, we present the multiresponsive and the nanocarriers bearing surface markers to target cancer cells. A short description has been given for the biological results of these nanocarriers. In this chapter, we cover all the main stimuli-responsive functionalities of the most recent literature.

Original languageEnglish
Title of host publicationStimuli Responsive Polymeric Nanocarriers for Drug Delivery Applications
Subtitle of host publicationVolume 2: Advanced Nanocarriers for Therapeutics
PublisherElsevier
Pages439-460
Number of pages22
ISBN (Electronic)9780081019955
ISBN (Print)9780081019962
DOIs
StatePublished - Jan 1 2018
Externally publishedYes

Keywords

  • Anticancer drugs
  • Cancer
  • Drug delivery
  • In vitro
  • In vivo
  • Micelles
  • Polymeric nanocarriers
  • Polypeptides
  • Stimuli-responsive

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