RefAHL: a curated quorum sensing reference linking diverse LuxI-type signal synthases with their acyl-homoserine lactone products

Amy L. Schaefer; Ethan G. Murdock; Dale A. Pelletier; Caroline S. Harwood; E. Peter Greenberg; Aaron W. Puri

doi:10.1128/mra.00407-25

RefAHL: a curated quorum sensing reference linking diverse LuxI-type signal synthases with their acyl-homoserine lactone products

Amy L. Schaefer
, Ethan G. Murdock
, Dale A. Pelletier
, Caroline S. Harwood
, E. Peter Greenberg
, Aaron W. Puri

Integrative Microbiomics

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Some bacteria use acyl-homoserine lactone (AHL) signals in quorum sensing, a type of cell-cell communication. Here, we present “RefAHL,” an updated, curated collection of LuxI-type AHL synthases with their AHL products and associated metadata. RefAHL is publicly available as a community resource to help catalog LuxI-type diversity encoded in (meta) genomic data.

Original language	English
Journal	Microbiology Resource Announcements
Volume	14
Issue number	6
DOIs	https://doi.org/10.1128/mra.00407-25
State	Published - Jun 2025

Funding

We are grateful to colleagues whose work is represented in the curated RefAHL list. The QS literature is extensive and, despite our best efforts, we likely missed some LuxI homologs with well-supported AHL signals. We encourage researchers to reach out if this is the case. National Institute of General Medical Sciences R35 GM118762 Aaron W. Puri National Institute of General Medical Sciences R35 GM136218 E. Peter Greenberg National Science Foundation 2339190 Aaron W. Puri U.S. Department of Energy DE-AC05-00OR22725 Amy L. Schaefer Dale A. Pelletier Caroline S. Harwood E. Peter Greenberg

Keywords

AHL
acyl-homoserine lactone
quorum sensing
sociomicrobiology

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10.1128/mra.00407-25

Cite this

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title = "RefAHL: a curated quorum sensing reference linking diverse LuxI-type signal synthases with their acyl-homoserine lactone products",

abstract = "Some bacteria use acyl-homoserine lactone (AHL) signals in quorum sensing, a type of cell-cell communication. Here, we present “RefAHL,” an updated, curated collection of LuxI-type AHL synthases with their AHL products and associated metadata. RefAHL is publicly available as a community resource to help catalog LuxI-type diversity encoded in (meta) genomic data.",

keywords = "AHL, acyl-homoserine lactone, quorum sensing, sociomicrobiology",

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language = "English",

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AU - Pelletier, Dale A.

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AU - Greenberg, E. Peter

AU - Puri, Aaron W.

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AB - Some bacteria use acyl-homoserine lactone (AHL) signals in quorum sensing, a type of cell-cell communication. Here, we present “RefAHL,” an updated, curated collection of LuxI-type AHL synthases with their AHL products and associated metadata. RefAHL is publicly available as a community resource to help catalog LuxI-type diversity encoded in (meta) genomic data.

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KW - acyl-homoserine lactone

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KW - sociomicrobiology

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ER -

RefAHL: a curated quorum sensing reference linking diverse LuxI-type signal synthases with their acyl-homoserine lactone products

Abstract

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Keywords

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