Reductive Coupling of CO2, Primary Amine, and Aldehyde at Room Temperature: A Versatile Approach to Unsymmetrically N,N-Disubstituted Formamides

Zhengang Ke; Leiduan Hao; Xiang Gao; Hongye Zhang; Yanfei Zhao; Bo Yu; Zhenzhen Yang; Yu Chen; Zhimin Liu

doi:10.1002/chem.201701420

Reductive Coupling of CO₂, Primary Amine, and Aldehyde at Room Temperature: A Versatile Approach to Unsymmetrically N,N-Disubstituted Formamides

Zhengang Ke, Leiduan Hao, Xiang Gao, Hongye Zhang, Yanfei Zhao, Bo Yu, Zhenzhen Yang, Yu Chen, Zhimin Liu

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

We present a simple, metal-free, and versatile route to synthesize unsymmetrically N,N-disubstituted formamides (NNFAs) from CO₂, primary amine, and aldehyde promoted by an ionic liquid (1-butyl-3-methylimidazolium chloride) at room temperature. This approach features wide scopes of amines and aldehydes, and various unsymmetrical NNFAs could be obtained in good to excellent yields. The ionic liquid can be reused for at least five runs without obvious activity loss.

Original language	English
Pages (from-to)	9721-9725
Number of pages	5
Journal	Chemistry - A European Journal
Volume	23
Issue number	41
DOIs	https://doi.org/10.1002/chem.201701420
State	Published - Jul 21 2017
Externally published	Yes

Funding

This work was financially supported by the National Natural Science Foundation of China (Nos. 21533011, 21403252, 21503239, 21125314) and the Chinese Academy of Sciences (QYZDY-SSW-SLH013).

Funders	Funder number
National Natural Science Foundation of China	21125314, 21403252, 21503239, 21533011
Chinese Academy of Sciences	QYZDY-SSW-SLH013

Keywords

aldehydes
carbon dioxide
formamides
primary amines
reductive coupling

Access to Document

10.1002/chem.201701420

Cite this

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abstract = "We present a simple, metal-free, and versatile route to synthesize unsymmetrically N,N-disubstituted formamides (NNFAs) from CO2, primary amine, and aldehyde promoted by an ionic liquid (1-butyl-3-methylimidazolium chloride) at room temperature. This approach features wide scopes of amines and aldehydes, and various unsymmetrical NNFAs could be obtained in good to excellent yields. The ionic liquid can be reused for at least five runs without obvious activity loss.",

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AU - Hao, Leiduan

AU - Gao, Xiang

AU - Zhang, Hongye

AU - Zhao, Yanfei

AU - Yu, Bo

AU - Yang, Zhenzhen

AU - Chen, Yu

AU - Liu, Zhimin

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AB - We present a simple, metal-free, and versatile route to synthesize unsymmetrically N,N-disubstituted formamides (NNFAs) from CO2, primary amine, and aldehyde promoted by an ionic liquid (1-butyl-3-methylimidazolium chloride) at room temperature. This approach features wide scopes of amines and aldehydes, and various unsymmetrical NNFAs could be obtained in good to excellent yields. The ionic liquid can be reused for at least five runs without obvious activity loss.

KW - aldehydes

KW - carbon dioxide

KW - formamides

KW - primary amines

KW - reductive coupling

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