Receptor-mediated intracellular delivery of PLGA nanoparticles coated with PLL-PEG-foIate conjugate

S. H. Kim, J. H. Jeong, K. W. Chun, T. G. Park

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

A di-block copolymer, poly(L-lysine)-b-poly (ethylene glycol)-folate (PLL-PEG-FA) conjugate, to be used as a targeted deliver carrier for poly(lactic-co-glycolic acid) (PLGA) nanoparticles was synthesized. KB cells were maintained on RPMI 1640 containing 10% fetal bovine serum. Particle sizes and surface charge of PLGA nanoparticles were 110 ± 2.2 nm and -17.8 ± 2.2 mv before coating and 106 ± 3.5 nm and 0.0 ± 0.8 mV after coating. It was suggested that the coating formulation using the PLL-PEG -FA conjugate can also be used to targeted delivery of other negatively charged macromolecules.

Original languageEnglish
Title of host publicationTransactions - 7th World Biomaterials Congress
Pages1804
Number of pages1
StatePublished - 2004
Externally publishedYes
EventTransactions - 7th World Biomaterials Congress - Sydney, Australia
Duration: May 17 2004May 21 2004

Publication series

NameTransactions - 7th World Biomaterials Congress

Conference

ConferenceTransactions - 7th World Biomaterials Congress
Country/TerritoryAustralia
CitySydney
Period05/17/0405/21/04

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