Recent advances in the probe development of technetium-99m molecular imaging agents

Paul D. Benny, Adam L. Moore

Research output: Contribution to journalReview articlepeer-review

8 Scopus citations

Abstract

The development of technetium based diagnostic imaging agents continues to remain a high impact area in nuclear medicine research. In particular, the single photon emitting radionuclide 99mTc comprises the majority of diagnostic imaging scans performed daily at hospitals and clinics. While research with 99mTc has been active for several decades, this review focuses on the overview of recent developments and current trends surrounding 99mTc applications. Discussion includes the fundamental design of 99mTc complexes, new labeling methodologies, and development of molecular probes for the next generation of in vivo diagnostic imaging agents.

Original languageEnglish
Pages (from-to)566-583
Number of pages18
JournalCurrent Organic Synthesis
Volume8
Issue number4
DOIs
StatePublished - Aug 2011
Externally publishedYes

Keywords

  • Complexes
  • Nuclear medicine
  • Radiopharmaceuticals
  • Spect
  • Technetium

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