Realization and properties of biochemical-computing biocatalytic XOR gate based on enzyme inhibition by a substrate

Jan Halámek; Vera Bocharova; Mary A. Arugula; Guinevere Strack; Vladimir Privman; Evgeny Katz

doi:10.1021/jp2041372

Realization and properties of biochemical-computing biocatalytic XOR gate based on enzyme inhibition by a substrate

Jan Halámek, Vera Bocharova, Mary A. Arugula, Guinevere Strack, Vladimir Privman, Evgeny Katz

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

We consider a realization of the XOR logic gate in a process biocatalyzed by an enzyme which can be inhibited by a substrate when the latter is inputted at large enough concentrations. A model is developed for describing such systems in an approach suitable for evaluation of the analog noise amplification properties of the gate. The obtained data are fitted for gate quality evaluation within the developed model, and we discuss aspects of devising XOR gates for functioning in "biocomputing" systems utilizing biomolecules for information processing.

Original language	English
Pages (from-to)	9838-9845
Number of pages	8
Journal	Journal of Physical Chemistry B
Volume	115
Issue number	32
DOIs	https://doi.org/10.1021/jp2041372
State	Published - Aug 18 2011
Externally published	Yes

Funding

Funders	Funder number
Directorate for Computer and Information Science and Engineering	1015983

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10.1021/jp2041372

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AU - Halámek, Jan

AU - Bocharova, Vera

AU - Arugula, Mary A.

AU - Strack, Guinevere

AU - Privman, Vladimir

AU - Katz, Evgeny

PY - 2011/8/18

Y1 - 2011/8/18

N2 - We consider a realization of the XOR logic gate in a process biocatalyzed by an enzyme which can be inhibited by a substrate when the latter is inputted at large enough concentrations. A model is developed for describing such systems in an approach suitable for evaluation of the analog noise amplification properties of the gate. The obtained data are fitted for gate quality evaluation within the developed model, and we discuss aspects of devising XOR gates for functioning in "biocomputing" systems utilizing biomolecules for information processing.

AB - We consider a realization of the XOR logic gate in a process biocatalyzed by an enzyme which can be inhibited by a substrate when the latter is inputted at large enough concentrations. A model is developed for describing such systems in an approach suitable for evaluation of the analog noise amplification properties of the gate. The obtained data are fitted for gate quality evaluation within the developed model, and we discuss aspects of devising XOR gates for functioning in "biocomputing" systems utilizing biomolecules for information processing.

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ER -

Realization and properties of biochemical-computing biocatalytic XOR gate based on enzyme inhibition by a substrate

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