TY - GEN
T1 - Quantitative elemental imaging with neutrons for breast cancer diagnosis
T2 - 2010 IEEE Nuclear Science Symposium, Medical Imaging Conference, NSS/MIC 2010 and 17th International Workshop on Room-Temperature Semiconductor X-ray and Gamma-ray Detectors, RTSD 2010
AU - Kapadia, Anuj J.
AU - Shah, Jainil P.
AU - Agasthya, Greeshma A.
PY - 2010
Y1 - 2010
N2 - Neutron stimulated emission computed tomography (NSECT) has been proposed as an early cancer-detection technique with the capability of 3-D tomographic imaging for identification of malignant tumors. In previous work we have demonstrated the ability of the technique to differentiate between normal and malignant breast tumors based on the concentration of cancer-marking elements in the tissue. Here we present tomographic images from a breast phantom with benign and malignant tumors simulated in GEANT4. A simulated model of the NSECT system was developed in GEANT4, along with phantoms corresponding to the human breast with benign and malignant tumors. Each tumor within the breast was given a different concentration of cancer-marking trace elements based on values reported in literature. The phantom was scanned with a 5-MeV neutron beam over a 180-degree angle. Tomographic images were reconstructed for six elements of interest from 10 different spectral lines. The results showed excellent agreement between the location of the tumor and the concentration of trace element detected in gamma lines from bromine, cesium, sodium and zinc. These results demonstrate the ability of NSECT in quantitative elemental imaging for breast cancer detection.
AB - Neutron stimulated emission computed tomography (NSECT) has been proposed as an early cancer-detection technique with the capability of 3-D tomographic imaging for identification of malignant tumors. In previous work we have demonstrated the ability of the technique to differentiate between normal and malignant breast tumors based on the concentration of cancer-marking elements in the tissue. Here we present tomographic images from a breast phantom with benign and malignant tumors simulated in GEANT4. A simulated model of the NSECT system was developed in GEANT4, along with phantoms corresponding to the human breast with benign and malignant tumors. Each tumor within the breast was given a different concentration of cancer-marking trace elements based on values reported in literature. The phantom was scanned with a 5-MeV neutron beam over a 180-degree angle. Tomographic images were reconstructed for six elements of interest from 10 different spectral lines. The results showed excellent agreement between the location of the tumor and the concentration of trace element detected in gamma lines from bromine, cesium, sodium and zinc. These results demonstrate the ability of NSECT in quantitative elemental imaging for breast cancer detection.
UR - http://www.scopus.com/inward/record.url?scp=79960305991&partnerID=8YFLogxK
U2 - 10.1109/NSSMIC.2010.5874363
DO - 10.1109/NSSMIC.2010.5874363
M3 - Conference contribution
AN - SCOPUS:79960305991
SN - 9781424491063
T3 - IEEE Nuclear Science Symposium Conference Record
SP - 3065
EP - 3068
BT - IEEE Nuclear Science Symposuim and Medical Imaging Conference, NSS/MIC 2010
Y2 - 30 October 2010 through 6 November 2010
ER -
