Protein structures by spallation neutron crystallography

Paul Langan, Zo Fisher, Andrii Kovalevsky, Marat Mustyakimov, Amanda Sutcliffe Valone, Cliff Unkefer, Mary Jo Waltman, Leighton Coates, Paul D. Adams, Pavel V. Afonine, Brad Bennett, Chris Dealwis, Benno P. Schoenborn

    Research output: Contribution to journalArticlepeer-review

    33 Scopus citations

    Abstract

    The Protein Crystallography Station at Los Alamos Neutron Science Center is a high-performance beamline that forms the core of a capability for neutron macromolecular structure and function determination. This capability also includes the Macromolecular Neutron Crystallography (MNC) consortium between Los Alamos (LANL) and Lawrence Berkeley National Laboratories for developing computational tools for neutron protein crystallography, a biological deuteration laboratory, the National Stable Isotope Production Facility, and an MNC drug design consortium between LANL and Case Western Reserve University.

    Original languageEnglish
    Pages (from-to)215-218
    Number of pages4
    JournalJournal of Synchrotron Radiation
    Volume15
    Issue number3
    DOIs
    StatePublished - Apr 18 2008

    Funding

    FundersFunder number
    National Institute of General Medical SciencesR01GM071939
    National Institute of General Medical Sciences

      Keywords

      • Deuteration
      • Drug binding
      • Enzyme mechanisms
      • Hydration
      • Joint XN structure refinement
      • Macromolecular crystallography
      • Neutrons
      • Proteins

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