Protein structures by spallation neutron crystallography

Paul Langan; Zo Fisher; Andrii Kovalevsky; Marat Mustyakimov; Amanda Sutcliffe Valone; Cliff Unkefer; Mary Jo Waltman; Leighton Coates; Paul D. Adams; Pavel V. Afonine; Brad Bennett; Chris Dealwis; Benno P. Schoenborn

doi:10.1107/S0909049508000824

Protein structures by spallation neutron crystallography

Paul Langan, Zo Fisher, Andrii Kovalevsky, Marat Mustyakimov, Amanda Sutcliffe Valone, Cliff Unkefer, Mary Jo Waltman, Leighton Coates, Paul D. Adams, Pavel V. Afonine, Brad Bennett, Chris Dealwis, Benno P. Schoenborn

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Abstract

The Protein Crystallography Station at Los Alamos Neutron Science Center is a high-performance beamline that forms the core of a capability for neutron macromolecular structure and function determination. This capability also includes the Macromolecular Neutron Crystallography (MNC) consortium between Los Alamos (LANL) and Lawrence Berkeley National Laboratories for developing computational tools for neutron protein crystallography, a biological deuteration laboratory, the National Stable Isotope Production Facility, and an MNC drug design consortium between LANL and Case Western Reserve University.

Original language	English
Pages (from-to)	215-218
Number of pages	4
Journal	Journal of Synchrotron Radiation
Volume	15
Issue number	3
DOIs	https://doi.org/10.1107/S0909049508000824
State	Published - Apr 18 2008

Keywords

Deuteration
Drug binding
Enzyme mechanisms
Hydration
Joint XN structure refinement
Macromolecular crystallography
Neutrons
Proteins

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10.1107/S0909049508000824

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abstract = "The Protein Crystallography Station at Los Alamos Neutron Science Center is a high-performance beamline that forms the core of a capability for neutron macromolecular structure and function determination. This capability also includes the Macromolecular Neutron Crystallography (MNC) consortium between Los Alamos (LANL) and Lawrence Berkeley National Laboratories for developing computational tools for neutron protein crystallography, a biological deuteration laboratory, the National Stable Isotope Production Facility, and an MNC drug design consortium between LANL and Case Western Reserve University.",

keywords = "Deuteration, Drug binding, Enzyme mechanisms, Hydration, Joint XN structure refinement, Macromolecular crystallography, Neutrons, Proteins",

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AU - Langan, Paul

AU - Fisher, Zo

AU - Kovalevsky, Andrii

AU - Mustyakimov, Marat

AU - Sutcliffe Valone, Amanda

AU - Unkefer, Cliff

AU - Waltman, Mary Jo

AU - Coates, Leighton

AU - Adams, Paul D.

AU - Afonine, Pavel V.

AU - Bennett, Brad

AU - Dealwis, Chris

AU - Schoenborn, Benno P.

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KW - Drug binding

KW - Enzyme mechanisms

KW - Hydration

KW - Joint XN structure refinement

KW - Macromolecular crystallography

KW - Neutrons

KW - Proteins

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Protein structures by spallation neutron crystallography

Abstract

Keywords

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