Abstract
Bovine serum albumin (BSA), a model protein drug, was encapsulated with a microparticle based on the blend of poly(D,L-lactic-co-glycolic acid) (PLGA) and poly(L-lactide)-g-oligo(ethylene glycol) (PLLA-g-oligoEG). Effects of PLLA-g-oligoEG in the blend on degradation, characteristic properties, and release behavior of the microparticle were studied. Drug loading efficiency increased with increase in the graft frequency of oligoEG in the graft copolymer in the blend. The release of BSA was found to be more efficient for microparticles based on the blend than on the PLGA, which is due to the faster protein diffusion through the swollen phase of the hydrogel-like structure. The microparticles based on the blend showed a slower degradation and a lower pH shift compared to that of PLGA.
| Original language | English |
|---|---|
| Pages (from-to) | 275-284 |
| Number of pages | 10 |
| Journal | Journal of Controlled Release |
| Volume | 76 |
| Issue number | 3 |
| DOIs | |
| State | Published - Oct 19 2001 |
| Externally published | Yes |
Funding
This work is supported in part from the National Research Laboratory (NRL) program (project No. 2000-N-NL-01-C-270) by the ministry of Science and Technology, South Korea.
| Funders | Funder number |
|---|---|
| National Research Laboratory | 2000-N-NL-01-C-270 |
| Ministerio de Ciencia y Tecnología |
Keywords
- Bovine serum albumin
- Microparticle
- PLLA-g-oligoEG
- Polymer degradation
- Protein release