Protein delivery from poly(lactic-co-glycolic acid) biodegradable microspheres: Release kinetics and stability issues

G. Crotts; Tae Gwan Park

doi:10.3109/02652049809008253

Protein delivery from poly(lactic-co-glycolic acid) biodegradable microspheres: Release kinetics and stability issues

G. Crotts, Tae Gwan Park

Research output: Contribution to journal › Article › peer-review

232 Scopus citations

Abstract

In this review paper, a variety of critical factors in the PLGA microsphere formulation which might affect the release kinetic rate as well as the protein stability will be examined in detail. Three model proteins, carbonic anhydrase, bovine serum albumin, and lysozyme, which were encapsulated within PLGA microspheres by using the water/oil/water (W/O/W) double emulsion solvent evaporation method are used for the study.

Original language	English
Pages (from-to)	699-713
Number of pages	15
Journal	Journal of Microencapsulation
Volume	15
Issue number	6
DOIs	https://doi.org/10.3109/02652049809008253
State	Published - 1998
Externally published	Yes

Keywords

Biodegradable
Microsphere
PLGA
Protein delivery
Release kinetics
Stability

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10.3109/02652049809008253

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abstract = "In this review paper, a variety of critical factors in the PLGA microsphere formulation which might affect the release kinetic rate as well as the protein stability will be examined in detail. Three model proteins, carbonic anhydrase, bovine serum albumin, and lysozyme, which were encapsulated within PLGA microspheres by using the water/oil/water (W/O/W) double emulsion solvent evaporation method are used for the study.",

keywords = "Biodegradable, Microsphere, PLGA, Protein delivery, Release kinetics, Stability",

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AB - In this review paper, a variety of critical factors in the PLGA microsphere formulation which might affect the release kinetic rate as well as the protein stability will be examined in detail. Three model proteins, carbonic anhydrase, bovine serum albumin, and lysozyme, which were encapsulated within PLGA microspheres by using the water/oil/water (W/O/W) double emulsion solvent evaporation method are used for the study.

KW - Biodegradable

KW - Microsphere

KW - PLGA

KW - Protein delivery

KW - Release kinetics

KW - Stability

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Protein delivery from poly(lactic-co-glycolic acid) biodegradable microspheres: Release kinetics and stability issues

Abstract

Keywords

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