Preparation and characterization of PEG/PLA multiblock and triblock copolymer

Hesong Zhao; Zhun Liu; Sanghyuk Park; Sang Ho Kim; Jung Hyun Kim; Longhai Piao

doi:10.5012/bkcs.2012.33.5.1638

Preparation and characterization of PEG/PLA multiblock and triblock copolymer

Hesong Zhao, Zhun Liu, Sanghyuk Park, Sang Ho Kim, Jung Hyun Kim, Longhai Piao

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

A series of poly (lactic acid) (PLA) and poly (ethylene glycol) (PEG) tri and multiblock copolymers with relatively high molecular weights were synthesized through the coupling reaction between the bis(acyl chloride) of carboxylated PLA and mono or dihydroxy PEG. The coupling reaction and the copolymer structures were monitored by nuclear magnetic resonance (NMR), Fourier transform infrared spectroscopy (FTIR) and gel permeation chromatography (GPC). The melting temperature (Tm) of PEG blocks decreased with the presence of PLA sequences attaching to PEG blocks. The CMC values were determined to be 10-145 mg/L depending on the length of PLA and PEG blocks and the structure of the block copolymers.

Original language	English
Pages (from-to)	1638-1642
Number of pages	5
Journal	Bulletin of the Korean Chemical Society
Volume	33
Issue number	5
DOIs	https://doi.org/10.5012/bkcs.2012.33.5.1638
State	Published - May 20 2012
Externally published	Yes

Keywords

Biodegradable
Biopolymers
Block copolymers
Multiblock
Triblock

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10.5012/bkcs.2012.33.5.1638

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title = "Preparation and characterization of PEG/PLA multiblock and triblock copolymer",

abstract = "A series of poly (lactic acid) (PLA) and poly (ethylene glycol) (PEG) tri and multiblock copolymers with relatively high molecular weights were synthesized through the coupling reaction between the bis(acyl chloride) of carboxylated PLA and mono or dihydroxy PEG. The coupling reaction and the copolymer structures were monitored by nuclear magnetic resonance (NMR), Fourier transform infrared spectroscopy (FTIR) and gel permeation chromatography (GPC). The melting temperature (Tm) of PEG blocks decreased with the presence of PLA sequences attaching to PEG blocks. The CMC values were determined to be 10-145 mg/L depending on the length of PLA and PEG blocks and the structure of the block copolymers.",

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T1 - Preparation and characterization of PEG/PLA multiblock and triblock copolymer

AU - Zhao, Hesong

AU - Liu, Zhun

AU - Park, Sanghyuk

AU - Kim, Sang Ho

AU - Kim, Jung Hyun

AU - Piao, Longhai

PY - 2012/5/20

Y1 - 2012/5/20

N2 - A series of poly (lactic acid) (PLA) and poly (ethylene glycol) (PEG) tri and multiblock copolymers with relatively high molecular weights were synthesized through the coupling reaction between the bis(acyl chloride) of carboxylated PLA and mono or dihydroxy PEG. The coupling reaction and the copolymer structures were monitored by nuclear magnetic resonance (NMR), Fourier transform infrared spectroscopy (FTIR) and gel permeation chromatography (GPC). The melting temperature (Tm) of PEG blocks decreased with the presence of PLA sequences attaching to PEG blocks. The CMC values were determined to be 10-145 mg/L depending on the length of PLA and PEG blocks and the structure of the block copolymers.

AB - A series of poly (lactic acid) (PLA) and poly (ethylene glycol) (PEG) tri and multiblock copolymers with relatively high molecular weights were synthesized through the coupling reaction between the bis(acyl chloride) of carboxylated PLA and mono or dihydroxy PEG. The coupling reaction and the copolymer structures were monitored by nuclear magnetic resonance (NMR), Fourier transform infrared spectroscopy (FTIR) and gel permeation chromatography (GPC). The melting temperature (Tm) of PEG blocks decreased with the presence of PLA sequences attaching to PEG blocks. The CMC values were determined to be 10-145 mg/L depending on the length of PLA and PEG blocks and the structure of the block copolymers.

KW - Biodegradable

KW - Biopolymers

KW - Block copolymers

KW - Multiblock

KW - Triblock

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M3 - Article

AN - SCOPUS:84861367013

SN - 0253-2964

VL - 33

SP - 1638

EP - 1642

JO - Bulletin of the Korean Chemical Society

JF - Bulletin of the Korean Chemical Society

IS - 5

ER -

Preparation and characterization of PEG/PLA multiblock and triblock copolymer

Abstract

Keywords

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