Predictive value of collagen in cancer

Peggi M. Angel; Stephen C. Zambrzycki

doi:10.1016/bs.acr.2022.02.004

Predictive value of collagen in cancer

Peggi M. Angel, Stephen C. Zambrzycki

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

15 Scopus citations

Abstract

Cancer is a complex disease and a significant cause of mortality worldwide. Over the course of nearly all cancer types, collagen within the tumor microenvironment influences emergence, progression, and metastasis. This review discusses collagen regulation within the tumor microenvironment, pathological involvement of collagen, and predictive values of collagen and related extracellular matrix components in main cancer types. A survey of predictive tests leveraging collagen assays using clinical cohorts is presented. A conclusion is that collagen has high predictive value in monitoring cancer processes and stratifying by outcomes. New approaches should be considered that continue to define molecular facets of collagen related to cancer.

Original language	English
Title of host publication	Stromal Signaling in Cancer
Editors	Peggi M. Angel
Publisher	Academic Press Inc.
Pages	15-45
Number of pages	31
ISBN (Print)	9780323854238
DOIs	https://doi.org/10.1016/bs.acr.2022.02.004
State	Published - Jan 2022
Externally published	Yes

Publication series

Name	Advances in Cancer Research
Volume	154
ISSN (Print)	0065-230X
ISSN (Electronic)	2162-5557

Funding

P.M.A. is supported by NIH/NCI R01CA253460; S.C.Z. is grateful for support from NIH/NCI T32CA193201.

Keywords

Breast cancer
Collagen
Extracellular matrix
Hepatocellular carcinoma
Lung cancer
Pancreatic ductal adenocarcinoma
Prediction
Prognosis
Progression
Prostate cancer
Stroma
Tumor

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/bs.acr.2022.02.004

Cite this

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title = "Predictive value of collagen in cancer",

abstract = "Cancer is a complex disease and a significant cause of mortality worldwide. Over the course of nearly all cancer types, collagen within the tumor microenvironment influences emergence, progression, and metastasis. This review discusses collagen regulation within the tumor microenvironment, pathological involvement of collagen, and predictive values of collagen and related extracellular matrix components in main cancer types. A survey of predictive tests leveraging collagen assays using clinical cohorts is presented. A conclusion is that collagen has high predictive value in monitoring cancer processes and stratifying by outcomes. New approaches should be considered that continue to define molecular facets of collagen related to cancer.",

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year = "2022",

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AU - Zambrzycki, Stephen C.

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AB - Cancer is a complex disease and a significant cause of mortality worldwide. Over the course of nearly all cancer types, collagen within the tumor microenvironment influences emergence, progression, and metastasis. This review discusses collagen regulation within the tumor microenvironment, pathological involvement of collagen, and predictive values of collagen and related extracellular matrix components in main cancer types. A survey of predictive tests leveraging collagen assays using clinical cohorts is presented. A conclusion is that collagen has high predictive value in monitoring cancer processes and stratifying by outcomes. New approaches should be considered that continue to define molecular facets of collagen related to cancer.

KW - Breast cancer

KW - Collagen

KW - Extracellular matrix

KW - Hepatocellular carcinoma

KW - Lung cancer

KW - Pancreatic ductal adenocarcinoma

KW - Prediction

KW - Prognosis

KW - Progression

KW - Prostate cancer

KW - Stroma

KW - Tumor

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M3 - Chapter

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T3 - Advances in Cancer Research

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BT - Stromal Signaling in Cancer

A2 - Angel, Peggi M.

PB - Academic Press Inc.

ER -

Predictive value of collagen in cancer

Abstract

Publication series

Funding

Keywords

UN SDGs

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