@article{775b210c5a9a41ca8cc99c986e411d46,
title = "Possible mechanism for cold denaturation of proteins at high pressure",
abstract = "We study cold denaturation of proteins at high pressures. Using multicanonical Monte Carlo simulations of a model protein in a water bath, we investigate the effect of water density fluctuations on protein stability. We find that above the pressure where water freezes to the dense ice phase ([Formula presented]) the mechanism for cold denaturation with decreasing temperature is the loss of local low-density water structure. We find our results in agreement with data of bovine pancreatic ribonuclease [Formula presented].",
author = "Marqu{\'e}s, {Manuel I.} and Borreguero, {Jose M.} and Stanley, {H. Eugene} and Dokholyan, {Nikolay V.}",
year = "2003",
doi = "10.1103/PhysRevLett.91.138103",
language = "English",
volume = "91",
journal = "Physical Review Letters",
issn = "0031-9007",
publisher = "American Physical Society",
number = "13",
}