Poly(lactic- co-glycolic acid) Nanoparticles as Delivery Systems for the Improved Administration of Radiotherapeutic Anticancer Agents

Michael W. Ambrogio, Miguel Toro-González, Tamara J. Keever, Timothy E. McKnight, Sandra M. Davern

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

This letter reports the development of poly(lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) as delivery systems that could potentially encapsulate and improve the administration of radiotherapeutic anticancer agents. Different metal ions (Ba, Gd, and Ce) were used as surrogates of α-emitting radionuclides (223Ra, 225Ac, and 227Th), and their encapsulation within the PLGA NPs (Dh < 300 nm) was evaluated. The initial concentration of metal ions, the metal salt (nitrate vs chloride), and the presence of chelators influenced the concentration of surrogate ions within the PLGA NPs. This letter shows the potential of PLGA NPs to encapsulate radionuclides, particularly α-emitters, for their application in nuclear medicine.

Original languageEnglish
Pages (from-to)10565-10570
Number of pages6
JournalACS Applied Nano Materials
Volume3
Issue number11
DOIs
StatePublished - Nov 25 2020

Funding

Research on the synthesis and characterization of the radiotherapeutic surrogates encapsulated within PLGA NPs throughout this investigation was sponsored by the Laboratory Directed Research and Development Program of Oak Ridge National Laboratory, managed by UT-Battelle, LLC, for the U.S. Department of Energy (DOE).

Keywords

  • drug delivery
  • nanoparticles
  • poly(lactic- co-glycolic acid)
  • radionuclides
  • targeted α-therapy

Fingerprint

Dive into the research topics of 'Poly(lactic- co-glycolic acid) Nanoparticles as Delivery Systems for the Improved Administration of Radiotherapeutic Anticancer Agents'. Together they form a unique fingerprint.

Cite this