Polyelectrolyte complex micelles composed of c-raf antisense oligodeoxynucleotide-poly(ethylene glycol) conjugate and poly(ethylenimine): Effect of systemic administration on tumor growth

Ji Hoon Jeong, Sun Hwa Kim, Sung Wan Kim, Tae Gwan Park

Research output: Contribution to journalArticlepeer-review

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Abstract

An antisense oligodeoxynucleotide (ODN) delivery system based on polyelectrolyte complex (PEC) micelles composed of an ODN-poly(ethylene glycol) (PEG) conjugate and polyethylenimine (PEI) was demonstrated. The PEC micelles having a core/shell structure were spontaneously formed in an aqueous solution by ionic interactions between ODN part in the conjugate and PEL The ODN/PEI polyelectrolyte complex formed an inner core while PEG chains surrounded it as a shell. The morphology of the micelles was visualized as a separate sphere by atomic force microscopy (AFM). When the micelles containing a c-raf antisense ODN were intravenously administered into tumor-bearing nude mice, significant antitumor activities against human lung cancer were observed. The intravenously injected micelles also showed significantly higher accumulation level in the solid tumor region compared to that of naked ODN.

Original languageEnglish
Pages (from-to)1034-1037
Number of pages4
JournalBioconjugate Chemistry
Volume16
Issue number4
DOIs
StatePublished - 2005
Externally publishedYes

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