Poly(DMAEMA-NVP)-b-PEG-galactose as an in vitro gene delivery vestor for hepatocytes

Dong Woo Lim; Tae Gwan Park

Poly(DMAEMA-NVP)-b-PEG-galactose as an in vitro gene delivery vestor for hepatocytes

Dong Woo Lim
, Tae Gwan Park

Research output: Contribution to journal › Conference article › peer-review

1 Scopus citations

Abstract

Poly(2-(dimethylamino)ethyl methacrylate (DMAEMA)) is studied in detail as a potential DNA carrier. Poly(DMAEMA) condenses plasmid DNA through ionic interaction, resulting in various transfection efficiencies depending on polymer/plasmid ratio. The presence of serum proteins, both polyethylene glycol (PEG) block and galactose targeting moiety which enhanced the gene transfection efficiency of poly(dimethylaminoethyl methacrylate-vinyl pyrrolidone)-b-polyethyleneglycol-galactose [(DMAEMA-NVP)-b-PEG-gal] is shown. In the absence of serum proteins, neither PEG nor galactose moiety in the polymer structure has no significant effect on the transfection efficiency.

Original language	English
Pages (from-to)	1008-1009
Number of pages	2
Journal	American Chemical Society, Polymer Preprints, Division of Polymer Chemistry
Volume	41
Issue number	1
State	Published - Mar 2000
Externally published	Yes
Event	The San Francisco Meeting - San Francisco, CA, USA Duration: Mar 26 2000 → Mar 31 2000

Cite this

@article{92df441528b94cc68305457ff5d75650,

title = "Poly(DMAEMA-NVP)-b-PEG-galactose as an in vitro gene delivery vestor for hepatocytes",

abstract = "Poly(2-(dimethylamino)ethyl methacrylate (DMAEMA)) is studied in detail as a potential DNA carrier. Poly(DMAEMA) condenses plasmid DNA through ionic interaction, resulting in various transfection efficiencies depending on polymer/plasmid ratio. The presence of serum proteins, both polyethylene glycol (PEG) block and galactose targeting moiety which enhanced the gene transfection efficiency of poly(dimethylaminoethyl methacrylate-vinyl pyrrolidone)-b-polyethyleneglycol-galactose [(DMAEMA-NVP)-b-PEG-gal] is shown. In the absence of serum proteins, neither PEG nor galactose moiety in the polymer structure has no significant effect on the transfection efficiency.",

author = "Lim, \{Dong Woo\} and Park, \{Tae Gwan\}",

year = "2000",

month = mar,

language = "English",

volume = "41",

pages = "1008--1009",

journal = "American Chemical Society, Polymer Preprints, Division of Polymer Chemistry",

issn = "0032-3934",

number = "1",

note = "The San Francisco Meeting ; Conference date: 26-03-2000 Through 31-03-2000",

}

TY - JOUR

T1 - Poly(DMAEMA-NVP)-b-PEG-galactose as an in vitro gene delivery vestor for hepatocytes

AU - Lim, Dong Woo

AU - Park, Tae Gwan

PY - 2000/3

Y1 - 2000/3

N2 - Poly(2-(dimethylamino)ethyl methacrylate (DMAEMA)) is studied in detail as a potential DNA carrier. Poly(DMAEMA) condenses plasmid DNA through ionic interaction, resulting in various transfection efficiencies depending on polymer/plasmid ratio. The presence of serum proteins, both polyethylene glycol (PEG) block and galactose targeting moiety which enhanced the gene transfection efficiency of poly(dimethylaminoethyl methacrylate-vinyl pyrrolidone)-b-polyethyleneglycol-galactose [(DMAEMA-NVP)-b-PEG-gal] is shown. In the absence of serum proteins, neither PEG nor galactose moiety in the polymer structure has no significant effect on the transfection efficiency.

AB - Poly(2-(dimethylamino)ethyl methacrylate (DMAEMA)) is studied in detail as a potential DNA carrier. Poly(DMAEMA) condenses plasmid DNA through ionic interaction, resulting in various transfection efficiencies depending on polymer/plasmid ratio. The presence of serum proteins, both polyethylene glycol (PEG) block and galactose targeting moiety which enhanced the gene transfection efficiency of poly(dimethylaminoethyl methacrylate-vinyl pyrrolidone)-b-polyethyleneglycol-galactose [(DMAEMA-NVP)-b-PEG-gal] is shown. In the absence of serum proteins, neither PEG nor galactose moiety in the polymer structure has no significant effect on the transfection efficiency.

UR - https://www.scopus.com/pages/publications/0033749143

M3 - Conference article

AN - SCOPUS:0033749143

SN - 0032-3934

VL - 41

SP - 1008

EP - 1009

JO - American Chemical Society, Polymer Preprints, Division of Polymer Chemistry

JF - American Chemical Society, Polymer Preprints, Division of Polymer Chemistry

IS - 1

T2 - The San Francisco Meeting

Y2 - 26 March 2000 through 31 March 2000

ER -

Poly(DMAEMA-NVP)-b-PEG-galactose as an in vitro gene delivery vestor for hepatocytes

Abstract

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