Abstract
Poly(2-(dimethylamino)ethyl methacrylate (DMAEMA)) is studied in detail as a potential DNA carrier. Poly(DMAEMA) condenses plasmid DNA through ionic interaction, resulting in various transfection efficiencies depending on polymer/plasmid ratio. The presence of serum proteins, both polyethylene glycol (PEG) block and galactose targeting moiety which enhanced the gene transfection efficiency of poly(dimethylaminoethyl methacrylate-vinyl pyrrolidone)-b-polyethyleneglycol-galactose [(DMAEMA-NVP)-b-PEG-gal] is shown. In the absence of serum proteins, neither PEG nor galactose moiety in the polymer structure has no significant effect on the transfection efficiency.
| Original language | English |
|---|---|
| Pages (from-to) | 1008-1009 |
| Number of pages | 2 |
| Journal | American Chemical Society, Polymer Preprints, Division of Polymer Chemistry |
| Volume | 41 |
| Issue number | 1 |
| State | Published - Mar 2000 |
| Externally published | Yes |
| Event | The San Francisco Meeting - San Francisco, CA, USA Duration: Mar 26 2000 → Mar 31 2000 |