Pluronic/polyethylenimine shell crosslinked nanocapsules with embedded magnetite nanocrystals for magnetically triggered delivery of siRNA

Kyuri Lee; Ki Hyun Bae; Yuhan Lee; Soo Hyeon Lee; Cheol Hee Ahn; Tae Gwan Park

doi:10.1002/mabi.200900291

Pluronic/polyethylenimine shell crosslinked nanocapsules with embedded magnetite nanocrystals for magnetically triggered delivery of siRNA

Kyuri Lee, Ki Hyun Bae, Yuhan Lee, Soo Hyeon Lee, Cheol Hee Ahn, Tae Gwan Park

Research output: Contribution to journal › Article › peer-review

53 Scopus citations

Abstract

Pluronic/polyethylenimine shell crosslinked nanocapsules with embedded magnetite nanocrystals (PPMCs) were developed for magnetically triggered delivery of siRNA. The positively charged PPMCs formed stable nanosized polyelectrolyte complexes via electrostatic interactions with negatively charged siRNA-polyethylene glycol conjugate (siRNA-s-s-PEG) that was linked via a cleavable disulfide linkage. PPMC/siRNA-s-s-PEG polyelectrolyte complexes were efficiently taken up by cancer cells upon exposure to a magnet, thereby enhancing intracellular uptake and silencing effect of siRNA. The present study suggests that these novel nanomaterials could be potentially utilized for magnetically triggered delivery of various nucleic acid-based therapeutic agents. (Figure Presented)

Original language	English
Pages (from-to)	239-245
Number of pages	7
Journal	Macromolecular Bioscience
Volume	10
Issue number	3
DOIs	https://doi.org/10.1002/mabi.200900291
State	Published - Mar 10 2010
Externally published	Yes

Keywords

Biomaterials
Composites
Drug delivery systems
Nanotechnology
Polyelectrolytes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/mabi.200900291

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title = "Pluronic/polyethylenimine shell crosslinked nanocapsules with embedded magnetite nanocrystals for magnetically triggered delivery of siRNA",

abstract = "Pluronic/polyethylenimine shell crosslinked nanocapsules with embedded magnetite nanocrystals (PPMCs) were developed for magnetically triggered delivery of siRNA. The positively charged PPMCs formed stable nanosized polyelectrolyte complexes via electrostatic interactions with negatively charged siRNA-polyethylene glycol conjugate (siRNA-s-s-PEG) that was linked via a cleavable disulfide linkage. PPMC/siRNA-s-s-PEG polyelectrolyte complexes were efficiently taken up by cancer cells upon exposure to a magnet, thereby enhancing intracellular uptake and silencing effect of siRNA. The present study suggests that these novel nanomaterials could be potentially utilized for magnetically triggered delivery of various nucleic acid-based therapeutic agents. (Figure Presented)",

keywords = "Biomaterials, Composites, Drug delivery systems, Nanotechnology, Polyelectrolytes",

author = "Kyuri Lee and Bae, {Ki Hyun} and Yuhan Lee and Lee, {Soo Hyeon} and Ahn, {Cheol Hee} and Park, {Tae Gwan}",

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doi = "10.1002/mabi.200900291",

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AU - Lee, Kyuri

AU - Bae, Ki Hyun

AU - Lee, Yuhan

AU - Lee, Soo Hyeon

AU - Ahn, Cheol Hee

AU - Park, Tae Gwan

PY - 2010/3/10

Y1 - 2010/3/10

N2 - Pluronic/polyethylenimine shell crosslinked nanocapsules with embedded magnetite nanocrystals (PPMCs) were developed for magnetically triggered delivery of siRNA. The positively charged PPMCs formed stable nanosized polyelectrolyte complexes via electrostatic interactions with negatively charged siRNA-polyethylene glycol conjugate (siRNA-s-s-PEG) that was linked via a cleavable disulfide linkage. PPMC/siRNA-s-s-PEG polyelectrolyte complexes were efficiently taken up by cancer cells upon exposure to a magnet, thereby enhancing intracellular uptake and silencing effect of siRNA. The present study suggests that these novel nanomaterials could be potentially utilized for magnetically triggered delivery of various nucleic acid-based therapeutic agents. (Figure Presented)

AB - Pluronic/polyethylenimine shell crosslinked nanocapsules with embedded magnetite nanocrystals (PPMCs) were developed for magnetically triggered delivery of siRNA. The positively charged PPMCs formed stable nanosized polyelectrolyte complexes via electrostatic interactions with negatively charged siRNA-polyethylene glycol conjugate (siRNA-s-s-PEG) that was linked via a cleavable disulfide linkage. PPMC/siRNA-s-s-PEG polyelectrolyte complexes were efficiently taken up by cancer cells upon exposure to a magnet, thereby enhancing intracellular uptake and silencing effect of siRNA. The present study suggests that these novel nanomaterials could be potentially utilized for magnetically triggered delivery of various nucleic acid-based therapeutic agents. (Figure Presented)

KW - Biomaterials

KW - Composites

KW - Drug delivery systems

KW - Nanotechnology

KW - Polyelectrolytes

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Pluronic/polyethylenimine shell crosslinked nanocapsules with embedded magnetite nanocrystals for magnetically triggered delivery of siRNA

Abstract

Keywords

UN SDGs

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