Piezoresistive measurement of Swine H1N1 Hemagglutinin peptide binding with microcantilever arrays

N. Bajwa, C. J. Maldonado, T. Thundat, A. Passian

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Effective detection of Swine H1N1 Hemagglutinin peptide is crucial as it could be used as a positive control to screen for highly infectious flu strains such as Swine-Origin Influenza A (H1N1). Piezoresistive microcantilever arrays present a pathway towards highly sensitive and label-free detection of biomolecules by transducing the antigen-antibody binding into change in resistivity via induced surface stress variation. We demonstrate a mechanical transduction of Swine H1N1 Hemagglutinin peptide binding and suggest the employed technique may offer a potential platform for detection of the H1N1 virus, which could be clinically used to diagnose and provide subsequent relief.

Original languageEnglish
Article number037118
JournalAIP Advances
Volume4
Issue number3
DOIs
StatePublished - Mar 2014

Funding

FundersFunder number
U.S. Department of EnergyDE-AC05-00OR22725

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