Phenyleneethynylene trimer-based rigid-flexible [2+2] macrocycles for nucleic acid labelling in live cells

Joong Ho Moon; Prakash Manandhar; Hooman Torabi; Md Rumum Rohman; Logesh Mathivathanan; Ka Hung Lee; Stephan Irle

doi:10.1039/c9cc02162k

Phenyleneethynylene trimer-based rigid-flexible [2+2] macrocycles for nucleic acid labelling in live cells

Joong Ho Moon, Prakash Manandhar, Hooman Torabi, Md Rumum Rohman, Logesh Mathivathanan, Ka Hung Lee, Stephan Irle

Computational Chemistry and Nanomaterial

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Fluorescent macromolecules were developed for intracellular labeling in live cells. Coupling rigid rod phenyleneethynylene trimers with flexible amphiphilic diamines via the imine-bond formation chemistry yielded rigid-flexible [2+2] macromolecules showing nucleic acid selectivity and nontoxicity in live cells.

Original language	English
Pages (from-to)	5930-5933
Number of pages	4
Journal	Chemical Communications
Volume	55
Issue number	42
DOIs	https://doi.org/10.1039/c9cc02162k
State	Published - 2019

Funding

JHM acknowledges generous financial support from the NSF (DMR 1352317). KHL and SI were supported by an LDRD grant from the ORNL.

Funders	Funder number
National Science Foundation	DMR 1352317
Oak Ridge National Laboratory
Laboratory Directed Research and Development

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10.1039/c9cc02162k

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abstract = "Fluorescent macromolecules were developed for intracellular labeling in live cells. Coupling rigid rod phenyleneethynylene trimers with flexible amphiphilic diamines via the imine-bond formation chemistry yielded rigid-flexible [2+2] macromolecules showing nucleic acid selectivity and nontoxicity in live cells.",

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AU - Moon, Joong Ho

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AU - Torabi, Hooman

AU - Rohman, Md Rumum

AU - Mathivathanan, Logesh

AU - Lee, Ka Hung

AU - Irle, Stephan

PY - 2019

Y1 - 2019

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AB - Fluorescent macromolecules were developed for intracellular labeling in live cells. Coupling rigid rod phenyleneethynylene trimers with flexible amphiphilic diamines via the imine-bond formation chemistry yielded rigid-flexible [2+2] macromolecules showing nucleic acid selectivity and nontoxicity in live cells.

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Phenyleneethynylene trimer-based rigid-flexible [2+2] macrocycles for nucleic acid labelling in live cells

Abstract

Funding

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