Phase transitions of reversed-phase stationary phases. Cause and effects in the mechanism of retention

John F. Wheeler; Thomas L. Beck; S. J. Klatte; Lynn A. Cole; John G. Dorsey

doi:10.1016/0021-9673(93)80807-K

Phase transitions of reversed-phase stationary phases. Cause and effects in the mechanism of retention

John F. Wheeler, Thomas L. Beck, S. J. Klatte, Lynn A. Cole, John G. Dorsey

Research output: Contribution to journal › Review article › peer-review

56 Scopus citations

Abstract

We provide a somewhat historical perspective on the work that has been accomplished that supports the suggestion of phase transitions in reversed-phase liquid chromatographic bonded phases. In addition to this general review, we consider from both a practical and theoretical viewpoint the implications of such transitions in the rational design of improved reversed-phase separations. Analytical theory and molecular simulation approaches to chromatographic stationary phases and related systems are reviewed. Initial results are presented on the temperature, density and chain length dependences of stationary phase properties. The role of computer simulation in analyzing transition behavior and retention processes is discussed.

Original language	English
Pages (from-to)	317-333
Number of pages	17
Journal	Journal of Chromatography A
Volume	656
Issue number	1-2
DOIs	https://doi.org/10.1016/0021-9673(93)80807-K
State	Published - Dec 17 1993
Externally published	Yes

Funding

J.G.D. is grateful for support of this work by AFOSR 91-0254a nd by NIH GM-48561.T .L.B. would like to thank the Donors of the Petroleum Research Fund of the American ChemicalS ocie-ty for partial support of this work. He also acknowledgesa grant of computer time on the Ohio SupercomputerC enter Cray-YMP.

Funders	Funder number
American ChemicalS ocie-ty
National Institutes of Health
National Institute of General Medical Sciences	R01GM048561
Air Force Office of Scientific Research	91-0254a

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AU - Wheeler, John F.

AU - Beck, Thomas L.

AU - Klatte, S. J.

AU - Cole, Lynn A.

AU - Dorsey, John G.

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AB - We provide a somewhat historical perspective on the work that has been accomplished that supports the suggestion of phase transitions in reversed-phase liquid chromatographic bonded phases. In addition to this general review, we consider from both a practical and theoretical viewpoint the implications of such transitions in the rational design of improved reversed-phase separations. Analytical theory and molecular simulation approaches to chromatographic stationary phases and related systems are reviewed. Initial results are presented on the temperature, density and chain length dependences of stationary phase properties. The role of computer simulation in analyzing transition behavior and retention processes is discussed.

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Phase transitions of reversed-phase stationary phases. Cause and effects in the mechanism of retention

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