pH- and temperature-sensitive multiblock copolymer hydrogels composed of poly(ethylene glycol) and poly(amino urethane)

Kasala Dayananda; Chaoliang He; Dong Kuk Park; Tae Gwan Park; Doo Sung Lee

doi:10.1016/j.polymer.2008.09.033

pH- and temperature-sensitive multiblock copolymer hydrogels composed of poly(ethylene glycol) and poly(amino urethane)

Kasala Dayananda
, Chaoliang He
, Dong Kuk Park
, Tae Gwan Park
, Doo Sung Lee

Research output: Contribution to journal › Article › peer-review

86 Scopus citations

Abstract

A series of novel pH- and temperature-responsive multiblock copolymers (poly(PEG/HEP urethane)) consisting of poly(ethylene glycol) (PEG) and poly(amino urethane) (PAU) were synthesized, and their physicochemical properties were studied. The amphiphilic block copolymers were synthesized from PEG, 1,4-bis(hydroxyethyl) piperazine (HEP) and 1,6-diisocyanato hexamethylene (HDI) in the presence of dibutyltin dilaurate as a catalyst. The resulting polymers were examined by FT-IR, ¹H and ¹³C NMR spectroscopies and gel permeation chromatography (GPC). The solution properties of the copolymers were studied by turbidity measurement and fluorescence spectroscopy. The copolymers showed a pH-dependent soluble-insoluble transition in diluted aqueous solutions. The concentrated polymer solutions exhibited a thermo-induced sol-gel-sol phase transition at pH 6.8-7.4. The gel window covers the physiological conditions. After a subcutaneous injection of the multiblock copolymer solution into mice, a transparent and soft gel was formed immediately. The in vitro release of a model anticancer drug, chlorambucil, persisted over 2 weeks under physiological conditions.

Original language	English
Pages (from-to)	4968-4973
Number of pages	6
Journal	Polymer
Volume	49
Issue number	23
DOIs	https://doi.org/10.1016/j.polymer.2008.09.033
State	Published - Oct 30 2008
Externally published	Yes

Funding

This work was supported by a “Korea Research Foundation Grant” (KRF-2006-005-J04602).

Keywords

Injectable hydrogel
Poly(amino urethane)
Stimuli-sensitive polymers

Access to Document

10.1016/j.polymer.2008.09.033

Cite this

@article{6d4df584fdb3427eb64a4ea16589a9dd,

title = "pH- and temperature-sensitive multiblock copolymer hydrogels composed of poly(ethylene glycol) and poly(amino urethane)",

abstract = "A series of novel pH- and temperature-responsive multiblock copolymers (poly(PEG/HEP urethane)) consisting of poly(ethylene glycol) (PEG) and poly(amino urethane) (PAU) were synthesized, and their physicochemical properties were studied. The amphiphilic block copolymers were synthesized from PEG, 1,4-bis(hydroxyethyl) piperazine (HEP) and 1,6-diisocyanato hexamethylene (HDI) in the presence of dibutyltin dilaurate as a catalyst. The resulting polymers were examined by FT-IR, 1H and 13C NMR spectroscopies and gel permeation chromatography (GPC). The solution properties of the copolymers were studied by turbidity measurement and fluorescence spectroscopy. The copolymers showed a pH-dependent soluble-insoluble transition in diluted aqueous solutions. The concentrated polymer solutions exhibited a thermo-induced sol-gel-sol phase transition at pH 6.8-7.4. The gel window covers the physiological conditions. After a subcutaneous injection of the multiblock copolymer solution into mice, a transparent and soft gel was formed immediately. The in vitro release of a model anticancer drug, chlorambucil, persisted over 2 weeks under physiological conditions.",

keywords = "Injectable hydrogel, Poly(amino urethane), Stimuli-sensitive polymers",

author = "Kasala Dayananda and Chaoliang He and Park, \{Dong Kuk\} and Park, \{Tae Gwan\} and Lee, \{Doo Sung\}",

year = "2008",

month = oct,

day = "30",

doi = "10.1016/j.polymer.2008.09.033",

language = "English",

volume = "49",

pages = "4968--4973",

journal = "Polymer",

issn = "0032-3861",

publisher = "Elsevier",

number = "23",

}

TY - JOUR

T1 - pH- and temperature-sensitive multiblock copolymer hydrogels composed of poly(ethylene glycol) and poly(amino urethane)

AU - Dayananda, Kasala

AU - He, Chaoliang

AU - Park, Dong Kuk

AU - Park, Tae Gwan

AU - Lee, Doo Sung

PY - 2008/10/30

Y1 - 2008/10/30

N2 - A series of novel pH- and temperature-responsive multiblock copolymers (poly(PEG/HEP urethane)) consisting of poly(ethylene glycol) (PEG) and poly(amino urethane) (PAU) were synthesized, and their physicochemical properties were studied. The amphiphilic block copolymers were synthesized from PEG, 1,4-bis(hydroxyethyl) piperazine (HEP) and 1,6-diisocyanato hexamethylene (HDI) in the presence of dibutyltin dilaurate as a catalyst. The resulting polymers were examined by FT-IR, 1H and 13C NMR spectroscopies and gel permeation chromatography (GPC). The solution properties of the copolymers were studied by turbidity measurement and fluorescence spectroscopy. The copolymers showed a pH-dependent soluble-insoluble transition in diluted aqueous solutions. The concentrated polymer solutions exhibited a thermo-induced sol-gel-sol phase transition at pH 6.8-7.4. The gel window covers the physiological conditions. After a subcutaneous injection of the multiblock copolymer solution into mice, a transparent and soft gel was formed immediately. The in vitro release of a model anticancer drug, chlorambucil, persisted over 2 weeks under physiological conditions.

AB - A series of novel pH- and temperature-responsive multiblock copolymers (poly(PEG/HEP urethane)) consisting of poly(ethylene glycol) (PEG) and poly(amino urethane) (PAU) were synthesized, and their physicochemical properties were studied. The amphiphilic block copolymers were synthesized from PEG, 1,4-bis(hydroxyethyl) piperazine (HEP) and 1,6-diisocyanato hexamethylene (HDI) in the presence of dibutyltin dilaurate as a catalyst. The resulting polymers were examined by FT-IR, 1H and 13C NMR spectroscopies and gel permeation chromatography (GPC). The solution properties of the copolymers were studied by turbidity measurement and fluorescence spectroscopy. The copolymers showed a pH-dependent soluble-insoluble transition in diluted aqueous solutions. The concentrated polymer solutions exhibited a thermo-induced sol-gel-sol phase transition at pH 6.8-7.4. The gel window covers the physiological conditions. After a subcutaneous injection of the multiblock copolymer solution into mice, a transparent and soft gel was formed immediately. The in vitro release of a model anticancer drug, chlorambucil, persisted over 2 weeks under physiological conditions.

KW - Injectable hydrogel

KW - Poly(amino urethane)

KW - Stimuli-sensitive polymers

UR - https://www.scopus.com/pages/publications/54249110943

U2 - 10.1016/j.polymer.2008.09.033

DO - 10.1016/j.polymer.2008.09.033

M3 - Article

AN - SCOPUS:54249110943

SN - 0032-3861

VL - 49

SP - 4968

EP - 4973

JO - Polymer

JF - Polymer

IS - 23

ER -

pH- and temperature-sensitive multiblock copolymer hydrogels composed of poly(ethylene glycol) and poly(amino urethane)

Abstract

Funding

Keywords

Access to Document

Other files and links

Fingerprint

Cite this