Peptide-based hydrogen sulphide-releasing gels

Jennifer M. Carter; Yun Qian; Jeffrey C. Foster; John B. Matson

doi:10.1039/c5cc04883d

Peptide-based hydrogen sulphide-releasing gels

Jennifer M. Carter, Yun Qian, Jeffrey C. Foster, John B. Matson

Research output: Contribution to journal › Article › peer-review

60 Scopus citations

Abstract

An aromatic peptide amphiphile was designed for delivery of the signaling gas H₂S. The peptide self-assembled in water into nanofibers that gelled upon charge screening. The non-toxic gel slowly released H₂S over 15 hours, and the presence of H₂S in endothelial cells was verified using a fluorescent H₂S probe.

Original language	English
Pages (from-to)	13131-13134
Number of pages	4
Journal	Chemical Communications
Volume	51
Issue number	66
DOIs	https://doi.org/10.1039/c5cc04883d
State	Published - Aug 25 2015
Externally published	Yes

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10.1039/c5cc04883d

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title = "Peptide-based hydrogen sulphide-releasing gels",

abstract = "An aromatic peptide amphiphile was designed for delivery of the signaling gas H2S. The peptide self-assembled in water into nanofibers that gelled upon charge screening. The non-toxic gel slowly released H2S over 15 hours, and the presence of H2S in endothelial cells was verified using a fluorescent H2S probe.",

author = "Carter, \{Jennifer M.\} and Yun Qian and Foster, \{Jeffrey C.\} and Matson, \{John B.\}",

note = "Publisher Copyright: {\textcopyright} 2015 The Royal Society of Chemistry.",

year = "2015",

month = aug,

day = "25",

doi = "10.1039/c5cc04883d",

language = "English",

volume = "51",

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T1 - Peptide-based hydrogen sulphide-releasing gels

AU - Carter, Jennifer M.

AU - Qian, Yun

AU - Foster, Jeffrey C.

AU - Matson, John B.

PY - 2015/8/25

Y1 - 2015/8/25

N2 - An aromatic peptide amphiphile was designed for delivery of the signaling gas H2S. The peptide self-assembled in water into nanofibers that gelled upon charge screening. The non-toxic gel slowly released H2S over 15 hours, and the presence of H2S in endothelial cells was verified using a fluorescent H2S probe.

AB - An aromatic peptide amphiphile was designed for delivery of the signaling gas H2S. The peptide self-assembled in water into nanofibers that gelled upon charge screening. The non-toxic gel slowly released H2S over 15 hours, and the presence of H2S in endothelial cells was verified using a fluorescent H2S probe.

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U2 - 10.1039/c5cc04883d

DO - 10.1039/c5cc04883d

M3 - Article

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SN - 1359-7345

VL - 51

SP - 13131

EP - 13134

JO - Chemical Communications

JF - Chemical Communications

IS - 66

ER -

Peptide-based hydrogen sulphide-releasing gels

Abstract

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