Palladium-catalyzed Br/D exchange of arenes: Selective deuterium incorporation with versatile functional group tolerance and high efficiency

Hong Hai Zhang; Peter V. Bonnesen; Kunlun Hong

doi:10.1039/c5qo00181a

Palladium-catalyzed Br/D exchange of arenes: Selective deuterium incorporation with versatile functional group tolerance and high efficiency

Macromolecular Nanomaterials

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Abstract

A facile method for introducing one or more deuterium atoms onto an aromatic nucleus via Br/D exchange with high functional group tolerance and high incorporation efficiency is disclosed. Deuterium-labeled aryl chlorides and aryl borates which could be used as substrates in cross-coupling reactions to construct more complicated deuterium-labeled compounds can also be synthesized by this method.

Original language	English
Pages (from-to)	1071-1075
Number of pages	5
Journal	Organic Chemistry Frontiers
Volume	2
Issue number	9
DOIs	https://doi.org/10.1039/c5qo00181a
State	Published - Sep 1 2015

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title = "Palladium-catalyzed Br/D exchange of arenes: Selective deuterium incorporation with versatile functional group tolerance and high efficiency",

abstract = "A facile method for introducing one or more deuterium atoms onto an aromatic nucleus via Br/D exchange with high functional group tolerance and high incorporation efficiency is disclosed. Deuterium-labeled aryl chlorides and aryl borates which could be used as substrates in cross-coupling reactions to construct more complicated deuterium-labeled compounds can also be synthesized by this method.",

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T2 - Selective deuterium incorporation with versatile functional group tolerance and high efficiency

AU - Zhang, Hong Hai

AU - Bonnesen, Peter V.

AU - Hong, Kunlun

N1 - Publisher Copyright: © the Partner Organisations 2015.

PY - 2015/9/1

Y1 - 2015/9/1

N2 - A facile method for introducing one or more deuterium atoms onto an aromatic nucleus via Br/D exchange with high functional group tolerance and high incorporation efficiency is disclosed. Deuterium-labeled aryl chlorides and aryl borates which could be used as substrates in cross-coupling reactions to construct more complicated deuterium-labeled compounds can also be synthesized by this method.

AB - A facile method for introducing one or more deuterium atoms onto an aromatic nucleus via Br/D exchange with high functional group tolerance and high incorporation efficiency is disclosed. Deuterium-labeled aryl chlorides and aryl borates which could be used as substrates in cross-coupling reactions to construct more complicated deuterium-labeled compounds can also be synthesized by this method.

UR - https://www.scopus.com/pages/publications/84939498426

U2 - 10.1039/c5qo00181a

DO - 10.1039/c5qo00181a

M3 - Article

AN - SCOPUS:84939498426

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JO - Organic Chemistry Frontiers

JF - Organic Chemistry Frontiers

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ER -

Palladium-catalyzed Br/D exchange of arenes: Selective deuterium incorporation with versatile functional group tolerance and high efficiency

Abstract

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