Over-Expression of the ATP5J Gene Correlates with Cell Migration and 5-Fluorouracil Sensitivity in Colorectal Cancer

Hongbo Zhu, Linlin Chen, Wei Zhou, Zhongting Huang, Jingzi Hu, Sheng Dai, Xiaowei Wang, Xuefeng Huang, Chao He

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

Recently we found that ATP5J was over-expressed in tissue samples from patients with colorectal cancer. However, the clinical significance and function of the over-expression of ATP5J in these patients remains unclear. We investigated these issues in the current study. Our results indicated that expression of ATP5J was significantly higher in colorectal cancer tissue than in adjacent tissue, and it was also significantly higher in metastatic lymph nodes than in primary cancer tissue (P<0.05). A correlation between ATP5J expression and tumor differentiation was detected, but no correlation with gender, age, T stage, lymph node metastasis, or survival status was observed. Down-regulation of ATP5J expression attenuated the ability of cell migration and increased the sensitivity to 5-fluorouracil (5-Fu) in cells of the DLD1 cell line. Inversely, up-regulation of ATP5J expression enhanced cell migration and decreased 5-Fu sensitivity, suggesting that the function of ATP5J in colorectal cancer might involve cell migration and 5-Fu sensitivity.

Original languageEnglish
Article numbere76846
JournalPLoS ONE
Volume8
Issue number10
DOIs
StatePublished - Oct 4 2013
Externally publishedYes

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