Open conformation of ezrin bound to phosphatidylinositol 4,5-bisphosphate and to F-actin revealed by neutron scattering

Jayant James Jayasundar, Jeong Ho Ju, Lilin He, Dazhi Liu, Flora Meilleur, Jinkui Zhao, David J.E. Callaway, Zimei Bu

Research output: Contribution to journalArticlepeer-review

38 Scopus citations

Abstract

Background: The structure of activated ezrin is not known. Results: We have determined the conformation of activated ezrin upon binding to PIP2 and to F-actin. Conclusion: Activated ezrin forms more extensive contacts with F-actin than generally depicted. Significance: This study provides new insight into the mechanisms by which ezrin assembles signaling complexes at the membrane-cytoskeleton interface.

Original languageEnglish
Pages (from-to)37119-37133
Number of pages15
JournalJournal of Biological Chemistry
Volume287
Issue number44
DOIs
StatePublished - Oct 26 2012

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