Numerical simulation of a compound capsule in a constricted microchannel

John Gounley; Erik W. Draeger; Amanda Randles

doi:10.1016/j.procs.2017.05.209

Numerical simulation of a compound capsule in a constricted microchannel

John Gounley, Erik W. Draeger, Amanda Randles

Research output: Contribution to journal › Conference article › peer-review

31 Scopus citations

Abstract

Simulations of the passage of eukaryotic cells through a constricted channel aid in studying the properties of cancer cells and their transport in the bloodstream. Compound capsules, which explicitly model the outer cell membrane and nuclear lamina, have the potential to improve computational model fidelity. However, general simulations of compound capsules transiting a constricted microchannel have not been conducted and the influence of the compound capsule model on computational performance is not well known. In this study, we extend a parallel hemodynamics application to simulate the fluid-structure interaction between compound capsules and fluid. With this framework, we compare the deformation of simple and compound capsules in constricted microchannels, and explore how deformation depends on the capillary number and on the volume fraction of the inner membrane. The computational framework's parallel performance in this setting is evaluated and future development lessons are discussed.

Original language	English
Pages (from-to)	175-184
Number of pages	10
Journal	Procedia Computer Science
Volume	108
DOIs	https://doi.org/10.1016/j.procs.2017.05.209
State	Published - 2017
Externally published	Yes
Event	International Conference on Computational Science ICCS 2017 - Zurich, Switzerland Duration: Jun 12 2017 → Jun 14 2017

Funding

Support was provided by the Department of Veterans Affairs' Big Data-Scientist Training Enhancement Program. Research reported in this publication was supported by the Office of the Director of the National Institutes of Health under Award Number DP5OD019876. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. This work was performed under the auspices of the U.S. Department of Energy by Lawrence Livermore National Laboratory under Contract DEAC52- 07NA27344. Computing support for this work came from Lawrence Livermore National Laboratory's Institutional Computing Grand Challenge program.

Funders	Funder number
National Institutes of Health	DP5OD019876
U.S. Department of Energy
U.S. Department of Veterans Affairs
Lawrence Livermore National Laboratory	DEAC52- 07NA27344

Keywords

capsules
fluid-structure interaction
lattice Boltzmann
parallel computing

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.procs.2017.05.209

Cite this

@article{28e3d1c6e91f4e53a7bdde4ff0ad099a,

title = "Numerical simulation of a compound capsule in a constricted microchannel",

abstract = "Simulations of the passage of eukaryotic cells through a constricted channel aid in studying the properties of cancer cells and their transport in the bloodstream. Compound capsules, which explicitly model the outer cell membrane and nuclear lamina, have the potential to improve computational model fidelity. However, general simulations of compound capsules transiting a constricted microchannel have not been conducted and the influence of the compound capsule model on computational performance is not well known. In this study, we extend a parallel hemodynamics application to simulate the fluid-structure interaction between compound capsules and fluid. With this framework, we compare the deformation of simple and compound capsules in constricted microchannels, and explore how deformation depends on the capillary number and on the volume fraction of the inner membrane. The computational framework's parallel performance in this setting is evaluated and future development lessons are discussed.",

keywords = "capsules, fluid-structure interaction, lattice Boltzmann, parallel computing",

author = "John Gounley and Draeger, {Erik W.} and Amanda Randles",

note = "Publisher Copyright: {\textcopyright} 2017 The Authors. Published by Elsevier B.V.; International Conference on Computational Science ICCS 2017 ; Conference date: 12-06-2017 Through 14-06-2017",

year = "2017",

doi = "10.1016/j.procs.2017.05.209",

language = "English",

volume = "108",

pages = "175--184",

journal = "Procedia Computer Science",

issn = "1877-0509",

publisher = "Elsevier",

}

TY - JOUR

T1 - Numerical simulation of a compound capsule in a constricted microchannel

AU - Gounley, John

AU - Draeger, Erik W.

AU - Randles, Amanda

PY - 2017

Y1 - 2017

N2 - Simulations of the passage of eukaryotic cells through a constricted channel aid in studying the properties of cancer cells and their transport in the bloodstream. Compound capsules, which explicitly model the outer cell membrane and nuclear lamina, have the potential to improve computational model fidelity. However, general simulations of compound capsules transiting a constricted microchannel have not been conducted and the influence of the compound capsule model on computational performance is not well known. In this study, we extend a parallel hemodynamics application to simulate the fluid-structure interaction between compound capsules and fluid. With this framework, we compare the deformation of simple and compound capsules in constricted microchannels, and explore how deformation depends on the capillary number and on the volume fraction of the inner membrane. The computational framework's parallel performance in this setting is evaluated and future development lessons are discussed.

AB - Simulations of the passage of eukaryotic cells through a constricted channel aid in studying the properties of cancer cells and their transport in the bloodstream. Compound capsules, which explicitly model the outer cell membrane and nuclear lamina, have the potential to improve computational model fidelity. However, general simulations of compound capsules transiting a constricted microchannel have not been conducted and the influence of the compound capsule model on computational performance is not well known. In this study, we extend a parallel hemodynamics application to simulate the fluid-structure interaction between compound capsules and fluid. With this framework, we compare the deformation of simple and compound capsules in constricted microchannels, and explore how deformation depends on the capillary number and on the volume fraction of the inner membrane. The computational framework's parallel performance in this setting is evaluated and future development lessons are discussed.

KW - capsules

KW - fluid-structure interaction

KW - lattice Boltzmann

KW - parallel computing

UR - http://www.scopus.com/inward/record.url?scp=85027357289&partnerID=8YFLogxK

U2 - 10.1016/j.procs.2017.05.209

DO - 10.1016/j.procs.2017.05.209

M3 - Conference article

AN - SCOPUS:85027357289

SN - 1877-0509

VL - 108

SP - 175

EP - 184

JO - Procedia Computer Science

JF - Procedia Computer Science

T2 - International Conference on Computational Science ICCS 2017

Y2 - 12 June 2017 through 14 June 2017

ER -

Numerical simulation of a compound capsule in a constricted microchannel

Abstract

Funding

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this