Nanotechnology and chip level systems for pressure driven liquid chromatography and emerging analytical separation techniques: A review

N. V. Lavrik, L. T. Taylor, M. J. Sepaniak

Research output: Contribution to journalShort surveypeer-review

52 Scopus citations

Abstract

Pressure driven liquid chromatography (LC) is a powerful and versatile separation technique particularly suitable for differentiating species present in extremely small quantities. This paper briefly reviews main historical trends and focuses on more recently developed technological approaches in miniaturization and on-chip integration of LC columns. The review emphasizes enabling technologies as well as main technological challenges specific to pressure driven separations and highlights emerging concepts that could ultimately overcome fundamental limitations of conventional LC columns.

Original languageEnglish
Pages (from-to)6-20
Number of pages15
JournalAnalytica Chimica Acta
Volume694
Issue number1-2
DOIs
StatePublished - May 23 2011

Keywords

  • HPLC
  • Liquid chromatography
  • Microfluidic
  • Nanocolumns
  • Pillar arrays
  • Pressure driven separation

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