TY - JOUR
T1 - Nanotechnologic biosensor ellipsometry and biomarker pattern analysis in the evaluation of atherosclerotic risk profile
AU - Siegel, G.
AU - Rodríguez, M.
AU - Sauer, F.
AU - Abletshauser, C.
AU - de Mey, C.
AU - Schötz, K.
AU - Ringstad, L.
AU - Malmsten, M.
AU - Schäfer, P.
PY - 2009/1/1
Y1 - 2009/1/1
N2 - A proteoheparan sulfate coated, hydrophobic silica surface serves as lipoprotein receptor at which the Ca2+-driven arteriosclerotic nanoplaque formation can be pursued by laser-based ellipsometry. Any lipoprotein from human blood can be very sensitively tested for its atherogenic properties. From the same blood sample, it is possible to determine the concentration and activity of a series of interacting biomarker molecules which, through a pattern analysis, allow to assess the state of health with respect to cardiovascular diseases. These two interlinked and complementary biosensors make a prospective cardio-cerebro-vascular risk stratification feasible, especially the sequelae of an underlying arteriosclerotic disease. Based on these diagnostic tools, an optimized therapy decision for the patient can be taken and the necessary preventive measures for the still healthy person.
AB - A proteoheparan sulfate coated, hydrophobic silica surface serves as lipoprotein receptor at which the Ca2+-driven arteriosclerotic nanoplaque formation can be pursued by laser-based ellipsometry. Any lipoprotein from human blood can be very sensitively tested for its atherogenic properties. From the same blood sample, it is possible to determine the concentration and activity of a series of interacting biomarker molecules which, through a pattern analysis, allow to assess the state of health with respect to cardiovascular diseases. These two interlinked and complementary biosensors make a prospective cardio-cerebro-vascular risk stratification feasible, especially the sequelae of an underlying arteriosclerotic disease. Based on these diagnostic tools, an optimized therapy decision for the patient can be taken and the necessary preventive measures for the still healthy person.
KW - Atherosclerotic risk profile
KW - Biomarker pattern analysis
KW - Ginkgo biloba
KW - Nanotechnologic biosensor ellipsometry
KW - Statins
KW - ω-3 fatty acids
UR - http://www.scopus.com/inward/record.url?scp=58149269067&partnerID=8YFLogxK
U2 - 10.1016/j.bios.2008.08.011
DO - 10.1016/j.bios.2008.08.011
M3 - Article
C2 - 18809309
AN - SCOPUS:58149269067
SN - 0956-5663
VL - 24
SP - 1512
EP - 1517
JO - Biosensors and Bioelectronics
JF - Biosensors and Bioelectronics
IS - 5
ER -
