Nanostructured ZnO-Based Electrochemical Sensor with Anionic Surfactant for the Electroanalysis of Trimethoprim

Vinoda B. Patil; Davalasab Ilager; Suresh M. Tuwar; Kunal Mondal; Nagaraj P. Shetti

doi:10.3390/bioengineering9100521

Nanostructured ZnO-Based Electrochemical Sensor with Anionic Surfactant for the Electroanalysis of Trimethoprim

Vinoda B. Patil, Davalasab Ilager, Suresh M. Tuwar, Kunal Mondal, Nagaraj P. Shetti

Nuclear Materials Packaging, Transportat

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

In this research, detection of trimethoprim (TMP) was carried out using a nanostructured zinc oxide nanoparticle-modified carbon paste electrode (ZnO/CPE) with an anionic surfactant and sodium dodecyl sulphate (SDS) with the help of voltametric techniques. The electrochemical nature of TMP was studied in 0.2 M pH 3.0 phosphate-buffer solution (PBS). The developed electrode displayed the highest peak current compared to nascent CPE. Effects of variation in different parameters, such as pH, immersion time, scan rate, and concentration, were investigated. The electrode process of TMP was irreversible and diffusion controlled with two electrons transferred. The effective concentration range (8.0 × 10⁻⁷ M–1.0 × 10⁻⁵ M) of TMP was obtained by varying the concentration with a lower limit of detection obtained to be 2.58 × 10⁻⁸ M. In addition, this approach was effectively employed in the detection of TMP in pharmaceutical dosages and samples of urine with the excellent recovery data, suggesting the potency of the developed electrode in clinical and pharmaceutical sample analysis.

Original language	English
Article number	521
Journal	Bioengineering
Volume	9
Issue number	10
DOIs	https://doi.org/10.3390/bioengineering9100521
State	Published - Oct 2022

Keywords

anionic surfactant
biomedical applications
electrochemical sensor
trimethoprim
zinc oxide nanoparticles

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10.3390/bioengineering9100521

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title = "Nanostructured ZnO-Based Electrochemical Sensor with Anionic Surfactant for the Electroanalysis of Trimethoprim",

abstract = "In this research, detection of trimethoprim (TMP) was carried out using a nanostructured zinc oxide nanoparticle-modified carbon paste electrode (ZnO/CPE) with an anionic surfactant and sodium dodecyl sulphate (SDS) with the help of voltametric techniques. The electrochemical nature of TMP was studied in 0.2 M pH 3.0 phosphate-buffer solution (PBS). The developed electrode displayed the highest peak current compared to nascent CPE. Effects of variation in different parameters, such as pH, immersion time, scan rate, and concentration, were investigated. The electrode process of TMP was irreversible and diffusion controlled with two electrons transferred. The effective concentration range (8.0 × 10−7 M–1.0 × 10−5 M) of TMP was obtained by varying the concentration with a lower limit of detection obtained to be 2.58 × 10−8 M. In addition, this approach was effectively employed in the detection of TMP in pharmaceutical dosages and samples of urine with the excellent recovery data, suggesting the potency of the developed electrode in clinical and pharmaceutical sample analysis.",

keywords = "anionic surfactant, biomedical applications, electrochemical sensor, trimethoprim, zinc oxide nanoparticles",

author = "Patil, {Vinoda B.} and Davalasab Ilager and Tuwar, {Suresh M.} and Kunal Mondal and Shetti, {Nagaraj P.}",

note = "Publisher Copyright: {\textcopyright} 2022 by the authors.",

year = "2022",

month = oct,

doi = "10.3390/bioengineering9100521",

language = "English",

volume = "9",

journal = "Bioengineering",

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T1 - Nanostructured ZnO-Based Electrochemical Sensor with Anionic Surfactant for the Electroanalysis of Trimethoprim

AU - Patil, Vinoda B.

AU - Ilager, Davalasab

AU - Tuwar, Suresh M.

AU - Mondal, Kunal

AU - Shetti, Nagaraj P.

PY - 2022/10

Y1 - 2022/10

N2 - In this research, detection of trimethoprim (TMP) was carried out using a nanostructured zinc oxide nanoparticle-modified carbon paste electrode (ZnO/CPE) with an anionic surfactant and sodium dodecyl sulphate (SDS) with the help of voltametric techniques. The electrochemical nature of TMP was studied in 0.2 M pH 3.0 phosphate-buffer solution (PBS). The developed electrode displayed the highest peak current compared to nascent CPE. Effects of variation in different parameters, such as pH, immersion time, scan rate, and concentration, were investigated. The electrode process of TMP was irreversible and diffusion controlled with two electrons transferred. The effective concentration range (8.0 × 10−7 M–1.0 × 10−5 M) of TMP was obtained by varying the concentration with a lower limit of detection obtained to be 2.58 × 10−8 M. In addition, this approach was effectively employed in the detection of TMP in pharmaceutical dosages and samples of urine with the excellent recovery data, suggesting the potency of the developed electrode in clinical and pharmaceutical sample analysis.

AB - In this research, detection of trimethoprim (TMP) was carried out using a nanostructured zinc oxide nanoparticle-modified carbon paste electrode (ZnO/CPE) with an anionic surfactant and sodium dodecyl sulphate (SDS) with the help of voltametric techniques. The electrochemical nature of TMP was studied in 0.2 M pH 3.0 phosphate-buffer solution (PBS). The developed electrode displayed the highest peak current compared to nascent CPE. Effects of variation in different parameters, such as pH, immersion time, scan rate, and concentration, were investigated. The electrode process of TMP was irreversible and diffusion controlled with two electrons transferred. The effective concentration range (8.0 × 10−7 M–1.0 × 10−5 M) of TMP was obtained by varying the concentration with a lower limit of detection obtained to be 2.58 × 10−8 M. In addition, this approach was effectively employed in the detection of TMP in pharmaceutical dosages and samples of urine with the excellent recovery data, suggesting the potency of the developed electrode in clinical and pharmaceutical sample analysis.

KW - anionic surfactant

KW - biomedical applications

KW - electrochemical sensor

KW - trimethoprim

KW - zinc oxide nanoparticles

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U2 - 10.3390/bioengineering9100521

DO - 10.3390/bioengineering9100521

M3 - Article

AN - SCOPUS:85140443419

SN - 2306-5354

VL - 9

JO - Bioengineering

JF - Bioengineering

IS - 10

M1 - 521

ER -

Nanostructured ZnO-Based Electrochemical Sensor with Anionic Surfactant for the Electroanalysis of Trimethoprim

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Keywords

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