TY - JOUR
T1 - Nanostructured microcantilevers with functionalized cyclodextrin receptor phases
T2 - Self-assembled monolayers and vapor-deposited films
AU - Tipple, Christopher A.
AU - Lavrik, Nickolay V.
AU - Culha, Mustafa
AU - Headrick, Jeremy
AU - Datskos, Panos
AU - Sepaniak, Michael J.
PY - 2002/7/1
Y1 - 2002/7/1
N2 - It is shown that the performance of microcantilver-based chemical sensors in a liquid environment is affected by altering cantilever surface morphology and receptor phase type and thickness. Self-assembled monolayers of thiolated β-cyclodextrin (HM-β-CD) and thin films of vapor-deposited heptakis (2,3-O-diacetyl-6-O-tertbutyl-dimethylsilyl)-β-cyclodextrin (HDATB-β-CD) were studied on smooth and nanostructured (dealloyed) gold-coated microcantilever surfaces. The dealloyed surface contains nanometer-sized features that enhance the transduction of molecular recognition events into cantilever response, as well as increase film stability for thicker films. Improvements in the limits of detection of the compound 2,3-dihydroxynaphthalene as great as 2 orders of magnitude have been achieved by manipulating surface morphology and film thickness. The observed response factors for the analytes studied varied from 0.02-604 nm/ppm, as determined by cantilever deflection. In general, calibration plots for the analytes were linear up to several hundred nanometers in cantilever deflections.
AB - It is shown that the performance of microcantilver-based chemical sensors in a liquid environment is affected by altering cantilever surface morphology and receptor phase type and thickness. Self-assembled monolayers of thiolated β-cyclodextrin (HM-β-CD) and thin films of vapor-deposited heptakis (2,3-O-diacetyl-6-O-tertbutyl-dimethylsilyl)-β-cyclodextrin (HDATB-β-CD) were studied on smooth and nanostructured (dealloyed) gold-coated microcantilever surfaces. The dealloyed surface contains nanometer-sized features that enhance the transduction of molecular recognition events into cantilever response, as well as increase film stability for thicker films. Improvements in the limits of detection of the compound 2,3-dihydroxynaphthalene as great as 2 orders of magnitude have been achieved by manipulating surface morphology and film thickness. The observed response factors for the analytes studied varied from 0.02-604 nm/ppm, as determined by cantilever deflection. In general, calibration plots for the analytes were linear up to several hundred nanometers in cantilever deflections.
UR - http://www.scopus.com/inward/record.url?scp=0036646557&partnerID=8YFLogxK
U2 - 10.1021/ac020074o
DO - 10.1021/ac020074o
M3 - Article
C2 - 12141672
AN - SCOPUS:0036646557
SN - 0003-2700
VL - 74
SP - 3118
EP - 3126
JO - Analytical Chemistry
JF - Analytical Chemistry
IS - 13
ER -