Abstract
Antimicrobial pentatopic 2,2′:6′,2′′-terpyridines that form 3-D supramolecular hexagonal prisms with Cd2+ through coordination driven self-assembly can be entrapped by lipid discoidal bicelles, composed of 1,2-dipalmitoyl-sn-glycero-3-phosphocholine, 1,2-dihexanoyl-sn-glycero-3-phosphocholine and 1,2-dipalmitoyl-sn-glycero-3-phospho-(1′-rac-glycerol) lipid, forming a well-defined nanocomplex. Structural characterization performed by very small angle neutron scattering, small angle X-ray scattering and transmission electron microscopy suggests that the hexagonal prisms are preferably located at the rim of bicellar discs with the hexagonal face in parallel with the bilayers, instead of face-to-face stacking. Such a configuration reduces the π-π interaction and consequently enhances the fluorescence emission. Since novel supramolecules were reported to have antibiotic functions, this study provides insight into the interactions of antimicrobial supermolecules with lipid membranes, leading to potential theranostic applications.
| Original language | English |
|---|---|
| Pages (from-to) | 14973-14979 |
| Number of pages | 7 |
| Journal | Nanoscale |
| Volume | 13 |
| Issue number | 35 |
| DOIs | |
| State | Published - Sep 21 2021 |
| Externally published | Yes |
Funding
The authors are grateful for the beamtime at the LiX beamline30,31 of NSLS-II (Brookhaven National Lab) through a beamtime proposal (BAG-302208). The LiX beamline is part of the Center for BioMolecular Structure (CBMS), primarily sup- ported by the National Institutes of Health, National Institute of General Medical Sciences through a Center Core P30 Grant (P30GM133893), and by the DOE Office of Biological and Environmental Research (KP1607011), with additional support from the NIH Grant S10OD012331. NSLS-II is a U.S. Department of Energy (DOE) Office of Science User Facility operated for the DOE Office of Science by Brookhaven National Laboratory under Contract no. DE-SC0012704. Access to vSANS was provided by the Center for High Resolution Neutron Scattering, a partnership between the National Institute of Standards and Technology and the National Science Foundation under Agreement no. DMR-2010792. Access to vSANS was provided by the Center for High Resolution Neutron Scattering, a partnership between the National Institute of Standards and Technology and the National Science Foundation under Agreement no. DMR-2010792. Certain commercial equipment, instruments, or materials (or suppliers, or software) are identified in this paper to foster understanding. Such identification does not imply recommendation or endorsement by the National Institute of Standards and Technology, nor does it imply that the materials or equipment identified are necessarily the best available for the purpose.
| Funders | Funder number |
|---|---|
| Center for BioMolecular Structure | |
| National Science Foundation | DMR-2010792 |
| National Institutes of Health | |
| U.S. Department of Energy | |
| NIH Office of the Director | S10OD012331 |
| National Institute of General Medical Sciences | P30GM133893 |
| National Institute of Standards and Technology | |
| Office of Science | |
| Biological and Environmental Research | KP1607011 |
| Brookhaven National Laboratory | DE-SC0012704 |