Abstract
Gadolinium vanadate nanoparticles (NPs) doped with europium, in concentrations between 5-40%, were synthesized via an aqueous route to prove their multimodal imaging functionalities and their performance as radionuclide carriers for targeted alpha therapy. Core-shell Gd0.8Eu0.2VO4 NPs were doped with the α-emitting actinium-225 to assess the in vitro retention of 225Ac and its decay daughters; francium-221 and bismuth-213. Gd0.8Eu0.2VO4 core-shell NPs were obtained using a precipitation synthesis route having a tetragonal system, a spherical morphology, and a uniform particle size distribution. Gd0.8Eu0.2VO4 core-shell NPs displayed the characteristic intense emission at 618 nm (red) and paramagnetic behavior of Eu and Gd cations, respectively. Partial retention of radionuclides was obtained with Gd0.8Eu0.2VO4 core NPs, while deposition of two nonradioactive Gd0.8Eu0.2VO4 shells significantly decreased the leakage of both 225Ac and 221Fr. The luminescence and magnetic functionalities as well as radionuclide retention capabilities of Gd0.8Eu0.2VO4 core-shell NPs demonstrate their potential for biomedical applications.
| Original language | English |
|---|---|
| Pages (from-to) | 7985-7997 |
| Number of pages | 13 |
| Journal | Journal of Materials Chemistry B |
| Volume | 6 |
| Issue number | 47 |
| DOIs | |
| State | Published - 2018 |
Funding
† This manuscript has been authored by UT-Battelle, LLC, under contract DE-AC05-00OR22725 with the US Department of Energy (DOE). The US government retains and the publisher, by accepting the article for publication, acknowledges that the US government retains a nonexclusive, paid-up, irrevocable, worldwide license to publish or reproduce the published form of this manuscript, or allow others to do so, for US government purposes. DOE will provide public access to these results of federally sponsored research in accordance with the DOE Public Access Plan (http://energy.gov/downloads/doe-public-access-plan). ‡ Electronic supplementary information (ESI) available. See DOI: 10.1039/ c8tb02173b This work was financed by the Virginia Commonwealth University (VCU) with the support of the Mechanical and Nuclear Engineering Department and NRC-HQ-84-14-FOA-002, Faculty Development Program in Radiation Detection and Health Physics at VCU. Work at ORNL was supported in part by (i) the US Department of Energy Isotope Program within the Office of Nuclear Physics and (ii) an appointment to the Oak Ridge National Laboratory Nuclear Engineering Science Laboratory Synthesis Program, sponsored by the US Department of Energy and administered by the Oak Ridge Institute for Science and Education. We would like to thank the staff of Nuclear and Radiochemistry Group at ORNL for their help with radiochemistry and radioactivity measurements. The authors also wish to thank Dr Joseph Turner from the Instrumentation Laboratory in the Department of Chemistry at VCU, the staff at the Nanomaterials Core Characterization Facility in the VCU College of Engineering and Dr Gary Tepper’s Laboratory for their assistance with fluorescence measurements and nano-materials characterization.