Multifractal texture analysis of perfusion lung scans as a potential diagnostic tool for acute pulmonary embolism

Georgia D. Tourassi, Erik D. Frederick, Carey E. Floyd, R. Edward Coleman

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

A computer-assisted diagnostic (CAD) tool was developed for the diagnosis of acute pulmonary embolism (PE) in perfusion lung scans. Forty-five scans (with angiographic proof) were included in the study. The CAD tool was composed of two modules. The first module performs multifractal texture analysis on the posterior view of the perfusion scan. The second module is a decision algorithm that merges the multifractal parameters into a diagnosis regarding the presence or absence of PE. Linear and non-linear decision models were evaluated for the diagnostic task. A consensus neural network significantly outperformed all decision models including the physicians.

Original languageEnglish
Pages (from-to)15-25
Number of pages11
JournalComputers in Biology and Medicine
Volume31
Issue number1
DOIs
StatePublished - Jan 2001
Externally publishedYes

Funding

This work was supported by grant RG 98-0324 from the Whitaker Foundation and in part by grant R29-HL-52826 from the National Heart, Lung, and Blood Institute.

FundersFunder number
National Heart, Lung, and Blood Institute
Whitaker FoundationR29-HL-52826

    Keywords

    • Computer-aided diagnosis
    • Fractal analysis
    • Image processing
    • Lung perfusion
    • Neural networks
    • Pulmonary embolism

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