Multi-scale biophysical principles in clinical irreversible electroporation

Daniel C. Sweeney; Robert E. Neal; Rafael V. Davalos

doi:10.1007/978-3-319-55113-5_3

Multi-scale biophysical principles in clinical irreversible electroporation

Daniel C. Sweeney, Robert E. Neal, Rafael V. Davalos

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

4 Scopus citations

Abstract

Irreversible electroporation (IRE) is a focal ablation methodology that involved generating brief, but intense, electric fields in a target tissue. These electric fields operate on the cell level to electrically perforate-or permeabilize-the cell membrane while maintaining the structural integrity of the extracellular components [12]. The development of IRE technology significantly improved the outcomes of patients with late-stage. A study investigating such outcomes found that the median survival of stage III pancreatic cancer patients rose from 6-13 to 24.9 months in a 200-person study following IRE treatment [31], roughly doubling patient posttreatment survival.

Original language	English
Title of host publication	Irreversible Electroporation in Clinical Practice
Publisher	Springer International Publishing
Pages	41-66
Number of pages	26
ISBN (Electronic)	9783319551135
ISBN (Print)	9783319551128
DOIs	https://doi.org/10.1007/978-3-319-55113-5_3
State	Published - Dec 27 2017
Externally published	Yes

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10.1007/978-3-319-55113-5_3

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title = "Multi-scale biophysical principles in clinical irreversible electroporation",

abstract = "Irreversible electroporation (IRE) is a focal ablation methodology that involved generating brief, but intense, electric fields in a target tissue. These electric fields operate on the cell level to electrically perforate-or permeabilize-the cell membrane while maintaining the structural integrity of the extracellular components [12]. The development of IRE technology significantly improved the outcomes of patients with late-stage. A study investigating such outcomes found that the median survival of stage III pancreatic cancer patients rose from 6-13 to 24.9 months in a 200-person study following IRE treatment [31], roughly doubling patient posttreatment survival.",

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AU - Neal, Robert E.

AU - Davalos, Rafael V.

PY - 2017/12/27

Y1 - 2017/12/27

N2 - Irreversible electroporation (IRE) is a focal ablation methodology that involved generating brief, but intense, electric fields in a target tissue. These electric fields operate on the cell level to electrically perforate-or permeabilize-the cell membrane while maintaining the structural integrity of the extracellular components [12]. The development of IRE technology significantly improved the outcomes of patients with late-stage. A study investigating such outcomes found that the median survival of stage III pancreatic cancer patients rose from 6-13 to 24.9 months in a 200-person study following IRE treatment [31], roughly doubling patient posttreatment survival.

AB - Irreversible electroporation (IRE) is a focal ablation methodology that involved generating brief, but intense, electric fields in a target tissue. These electric fields operate on the cell level to electrically perforate-or permeabilize-the cell membrane while maintaining the structural integrity of the extracellular components [12]. The development of IRE technology significantly improved the outcomes of patients with late-stage. A study investigating such outcomes found that the median survival of stage III pancreatic cancer patients rose from 6-13 to 24.9 months in a 200-person study following IRE treatment [31], roughly doubling patient posttreatment survival.

UR - https://www.scopus.com/pages/publications/85054946153

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EP - 66

BT - Irreversible Electroporation in Clinical Practice

PB - Springer International Publishing

ER -

Multi-scale biophysical principles in clinical irreversible electroporation

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