Multi-scale biophysical principles in clinical irreversible electroporation

Daniel C. Sweeney; Robert E. Neal; Rafael V. Davalos

doi:10.1007/978-3-319-55113-5_3

Multi-scale biophysical principles in clinical irreversible electroporation

Daniel C. Sweeney, Robert E. Neal, Rafael V. Davalos

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

3 Scopus citations

Abstract

Irreversible electroporation (IRE) is a focal ablation methodology that involved generating brief, but intense, electric fields in a target tissue. These electric fields operate on the cell level to electrically perforate-or permeabilize-the cell membrane while maintaining the structural integrity of the extracellular components [12]. The development of IRE technology significantly improved the outcomes of patients with late-stage. A study investigating such outcomes found that the median survival of stage III pancreatic cancer patients rose from 6-13 to 24.9 months in a 200-person study following IRE treatment [31], roughly doubling patient posttreatment survival.

Original language	English
Title of host publication	Irreversible Electroporation in Clinical Practice
Publisher	Springer International Publishing
Pages	41-66
Number of pages	26
ISBN (Electronic)	9783319551135
ISBN (Print)	9783319551128
DOIs	https://doi.org/10.1007/978-3-319-55113-5_3
State	Published - Dec 27 2017
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1007/978-3-319-55113-5_3

Cite this

@inbook{a6440fd89bfc4ff49a7e790ca6b5eae4,

title = "Multi-scale biophysical principles in clinical irreversible electroporation",

abstract = "Irreversible electroporation (IRE) is a focal ablation methodology that involved generating brief, but intense, electric fields in a target tissue. These electric fields operate on the cell level to electrically perforate-or permeabilize-the cell membrane while maintaining the structural integrity of the extracellular components [12]. The development of IRE technology significantly improved the outcomes of patients with late-stage. A study investigating such outcomes found that the median survival of stage III pancreatic cancer patients rose from 6-13 to 24.9 months in a 200-person study following IRE treatment [31], roughly doubling patient posttreatment survival.",

author = "Sweeney, {Daniel C.} and Neal, {Robert E.} and Davalos, {Rafael V.}",

note = "Publisher Copyright: {\textcopyright} Springer International Publishing AG 2018.",

year = "2017",

month = dec,

day = "27",

doi = "10.1007/978-3-319-55113-5_3",

language = "English",

isbn = "9783319551128",

pages = "41--66",

booktitle = "Irreversible Electroporation in Clinical Practice",

publisher = "Springer International Publishing",

}

TY - CHAP

T1 - Multi-scale biophysical principles in clinical irreversible electroporation

AU - Sweeney, Daniel C.

AU - Neal, Robert E.

AU - Davalos, Rafael V.

PY - 2017/12/27

Y1 - 2017/12/27

N2 - Irreversible electroporation (IRE) is a focal ablation methodology that involved generating brief, but intense, electric fields in a target tissue. These electric fields operate on the cell level to electrically perforate-or permeabilize-the cell membrane while maintaining the structural integrity of the extracellular components [12]. The development of IRE technology significantly improved the outcomes of patients with late-stage. A study investigating such outcomes found that the median survival of stage III pancreatic cancer patients rose from 6-13 to 24.9 months in a 200-person study following IRE treatment [31], roughly doubling patient posttreatment survival.

AB - Irreversible electroporation (IRE) is a focal ablation methodology that involved generating brief, but intense, electric fields in a target tissue. These electric fields operate on the cell level to electrically perforate-or permeabilize-the cell membrane while maintaining the structural integrity of the extracellular components [12]. The development of IRE technology significantly improved the outcomes of patients with late-stage. A study investigating such outcomes found that the median survival of stage III pancreatic cancer patients rose from 6-13 to 24.9 months in a 200-person study following IRE treatment [31], roughly doubling patient posttreatment survival.

UR - http://www.scopus.com/inward/record.url?scp=85054946153&partnerID=8YFLogxK

U2 - 10.1007/978-3-319-55113-5_3

DO - 10.1007/978-3-319-55113-5_3

M3 - Chapter

AN - SCOPUS:85054946153

SN - 9783319551128

SP - 41

EP - 66

BT - Irreversible Electroporation in Clinical Practice

PB - Springer International Publishing

ER -

Multi-scale biophysical principles in clinical irreversible electroporation

Abstract

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this