Modulation of cell proliferation by heterotrimeric G protein in Arabidopsis

H. Ullah; J. G. Chen; J. C. Young; K. H. Im; M. R. Sussman; A. M. Jones

doi:10.1126/science.1059040

Modulation of cell proliferation by heterotrimeric G protein in Arabidopsis

H. Ullah, J. G. Chen, J. C. Young, K. H. Im, M. R. Sussman, A. M. Jones

Research output: Contribution to journal › Article › peer-review

306 Scopus citations

Abstract

The α subunit of a prototypical heterotrimeric GTP-binding protein (G protein), which is encoded by a single gene (GPA1) in Arabidopsis, is a modulator of plant cell proliferation, gpa1 null mutants have reduced cell division in aerial tissues throughout development. Inducible overexpression of GPA1 in Arabidopsis confers inducible ectopic cell division. GPA1 overexpression in synchronized BY-2 cells causes premature advance of the nuclear cycle and the premature appearance of a division wall. Results from loss of function and ectopic expression and activation of GPA1 indicate that this subunit is a positive modulator of cell division in plants.

Original language	English
Pages (from-to)	2066-2069
Number of pages	4
Journal	Science
Volume	292
Issue number	5524
DOIs	https://doi.org/10.1126/science.1059040
State	Published - Jun 15 2001
Externally published	Yes

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title = "Modulation of cell proliferation by heterotrimeric G protein in Arabidopsis",

abstract = "The α subunit of a prototypical heterotrimeric GTP-binding protein (G protein), which is encoded by a single gene (GPA1) in Arabidopsis, is a modulator of plant cell proliferation, gpa1 null mutants have reduced cell division in aerial tissues throughout development. Inducible overexpression of GPA1 in Arabidopsis confers inducible ectopic cell division. GPA1 overexpression in synchronized BY-2 cells causes premature advance of the nuclear cycle and the premature appearance of a division wall. Results from loss of function and ectopic expression and activation of GPA1 indicate that this subunit is a positive modulator of cell division in plants.",

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AU - Chen, J. G.

AU - Young, J. C.

AU - Im, K. H.

AU - Sussman, M. R.

AU - Jones, A. M.

PY - 2001/6/15

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AB - The α subunit of a prototypical heterotrimeric GTP-binding protein (G protein), which is encoded by a single gene (GPA1) in Arabidopsis, is a modulator of plant cell proliferation, gpa1 null mutants have reduced cell division in aerial tissues throughout development. Inducible overexpression of GPA1 in Arabidopsis confers inducible ectopic cell division. GPA1 overexpression in synchronized BY-2 cells causes premature advance of the nuclear cycle and the premature appearance of a division wall. Results from loss of function and ectopic expression and activation of GPA1 indicate that this subunit is a positive modulator of cell division in plants.

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JO - Science

JF - Science

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ER -

Modulation of cell proliferation by heterotrimeric G protein in Arabidopsis

Abstract

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