TY - JOUR
T1 - Modeling of micro/nano particle separation in microchannels with field-flow fractionation
AU - Song, Minghao
AU - Sun, Hongwei
AU - Charmchi, Majid
AU - Wang, Pengtao
AU - Zhang, Zongqin
AU - Faghri, Mohammad
PY - 2010/6
Y1 - 2010/6
N2 - The cyclical electrical field-flow fractionation (CyElFFF) is a very promising separation technique for particles and biological molecules such as proteins, nucleic acids, viruses, bacteria, yeast cells, mammalian cells. But a clear understanding of the mechanism and performance prediction of this system under different operating parameters is far from completed. This research focuses on a computational investigation of particle behavior in a CyElFFF system by taking into account both electrokinetic effects and particle dynamics. The model was validated with both theory and experimental results. The effects of key parameters such as applied electric field strength and frequency, solution fluid flow rate, particle size, particle shape on separation process are addressed in a systematic way. The developed model can also be utilized in studying the behavior of spherical or non-spherical particles (such as nanowire, nanorod, and nanofiber) in other microfluidic systems.
AB - The cyclical electrical field-flow fractionation (CyElFFF) is a very promising separation technique for particles and biological molecules such as proteins, nucleic acids, viruses, bacteria, yeast cells, mammalian cells. But a clear understanding of the mechanism and performance prediction of this system under different operating parameters is far from completed. This research focuses on a computational investigation of particle behavior in a CyElFFF system by taking into account both electrokinetic effects and particle dynamics. The model was validated with both theory and experimental results. The effects of key parameters such as applied electric field strength and frequency, solution fluid flow rate, particle size, particle shape on separation process are addressed in a systematic way. The developed model can also be utilized in studying the behavior of spherical or non-spherical particles (such as nanowire, nanorod, and nanofiber) in other microfluidic systems.
UR - http://www.scopus.com/inward/record.url?scp=77952425327&partnerID=8YFLogxK
U2 - 10.1007/s00542-010-1054-4
DO - 10.1007/s00542-010-1054-4
M3 - Article
AN - SCOPUS:77952425327
SN - 0946-7076
VL - 16
SP - 947
EP - 954
JO - Microsystem Technologies
JF - Microsystem Technologies
IS - 6
ER -