@article{a540d59c9ef6408d9dc9b3bedfad98cc,
title = "Mixed plastics waste valorization through tandem chemical oxidation and biological funneling",
abstract = "Mixed plastics waste represents an abundant and largely untapped feedstock for the production of valuable products. The chemical diversity and complexity of these materials, however, present major barriers to realizing this opportunity. In this work, we show that metal-catalyzed autoxidation depolymerizes comingled polymers into a mixture of oxygenated small molecules that are advantaged substrates for biological conversion. We engineer a robust soil bacterium, Pseudomonas putida, to funnel these oxygenated compounds into a single exemplary chemical product, either b-ketoadipate or polyhydroxyalkanoates. This hybrid process establishes a strategy for the selective conversion of mixed plastics waste into useful chemical products.",
author = "Sullivan, {Kevin P.} and Werner, {Allison Z.} and Ramirez, {Kelsey J.} and Ellis, {Lucas D.} and Bussard, {Jeremy R.} and Black, {Brenna A.} and Brandner, {David G.} and Felicia Bratti and Buss, {Bonnie L.} and Xueming Dong and Haugen, {Stefan J.} and Ingraham, {Morgan A.} and Konev, {Mikhail O.} and Michener, {William E.} and Joel Miscall and Isabel Pardo and Woodworth, {Sean P.} and Guss, {Adam M.} and Yuriy Rom{\'a}n-Leshkov and Stahl, {Shannon S.} and Beckham, {Gregg T.}",
note = "Publisher Copyright: {\textcopyright} 2022 American Association for the Advancement of Science. All rights reserved.",
year = "2022",
month = oct,
day = "14",
doi = "10.1126/science.abo4626",
language = "English",
volume = "378",
journal = "Science",
issn = "0036-8075",
publisher = "American Association for the Advancement of Science",
number = "6616",
}