Microscale and nanoscale compartments for biotechnology

Scott T. Retterer, Michael L. Simpson

Research output: Contribution to journalReview articlepeer-review

15 Scopus citations

Abstract

Compartmentalization is essential in the organization of biological systems, playing a fundamental role in modulating biochemical activity. An appreciation of the impact that biological compartments have on chemical reactions and an understanding of the physical and chemical phenomena that affect their assembly and function have inspired the development of synthetic compartments. Organic compartments assembled from amphiphilic molecules or derived from biological materials, have formed the basis of initial work in the field. However, inorganic and hybrid organic-inorganic compartments that capitalize on the optical and catalytic properties of metal and semiconductor materials are emerging. Methods for arraying these microcompartment and nanocompartment materials in higher order systems promise to enable the scaling and integration of these technologies for industrial and commercial applications.

Original languageEnglish
Pages (from-to)522-528
Number of pages7
JournalCurrent Opinion in Biotechnology
Volume23
Issue number4
DOIs
StatePublished - Aug 2012

Funding

The authors acknowledge support from the Center for Nanophase Materials Sciences, which is sponsored at Oak Ridge National Laboratory by the Office of Basic Energy Sciences, U.S. Department of Energy. Oak Ridge National Laboratory is managed by UT-Battelle, LLC, for the U.S. DOE under Contract No. DE-AC05-00OR22725.

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