MicroPET: A high resolution PET scanner for imaging small animals

S. R. Cherry; Y. Shao; R. W. Silverman; K. Meadors; S. Siegel; A. Chatziioannou; J. W. Young; W. F. Jones; J. C. Moyers; D. Newport; A. Boutefnouchet; T. H. Farquhar; M. Andreaco; M. J. Paulus; D. M. Binkley; R. Nutt; M. E. Phelps

doi:10.1109/23.596981

MicroPET: A high resolution PET scanner for imaging small animals

S. R. Cherry, Y. Shao, R. W. Silverman, K. Meadors, S. Siegel, A. Chatziioannou, J. W. Young, W. F. Jones, J. C. Moyers, D. Newport, A. Boutefnouchet, T. H. Farquhar, M. Andreaco, M. J. Paulus, D. M. Binkley, R. Nutt, M. E. Phelps

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Abstract

MicroPET is a high resolution positron emission tomography (PET) scanner designed for imaging small laboratory animals. It consists of a ring of 30 positionsensitive scintillation detectors, each with an 8 x 8 array of small lutetium oxyorthosilicate (LSO) crystals coupled via optical fibers to a multi-channel photomultiplier tube. The detectors have an intrinsic resolution averaging 1.68 mm, an energy resolution between 15 and 25% and 2.4 ns timing resolution at 511 keV. The detector ring diameter of microPET is 17.2 cm with an imaging field of view of 112 mm transaxially by 18 mm axially. The scanner has no septa and operates exclusively in 3D mode. Reconstructed image resolution 1 cm from the center of the scanner is 2.0 mm and virtually isotropic, yielding a volume resolution of 8 mm³. For comparison, the volume resolution of state-of-the-art clinical PET systems is in the range of 50 - 75 mnA Initial images of phantoms have been acquired and are reported. A computer controlled bed is under construction and will incorporate a small wobble motion to improve spatial sampling. This is projected to further enhance spatial resolution. MicroPET is the first PET scanner to incorporate the new scintillator LSO and to our knowledge is the highest resolution multi-ring PET scanner currently in existence.

Original language	English
Pages (from-to)	1161-1166
Number of pages	6
Journal	IEEE Transactions on Nuclear Science
Volume	44
Issue number	3 PART 2
DOIs	https://doi.org/10.1109/23.596981
State	Published - 1997
Externally published	Yes

Funding

We would like to thank Wayne Seemungal and Esso Fiykt (Philips Components), Stan Majewski (TJNAF), Gary Hutchins and Tony Simon (Indiana University), T.J. Paulus (PEC) and Sam Gambhir, Parag Shah, David Truong, Kent Gardner and Bill Larkin (UCLA) for their assistance. We also thank the staff of the UCLA PET Center and Cyclotron for providing the isotopes used in this work. This project is supported by the Ahmanson Foundation, the UCLA Cancer Center, the Norton Simon Fund, Department of Energy Contract DE-FC03-87-ER60615 and by grants from the Whitaker Foundation (J100193) and the National Institutes of Health (R01 CA69370).

Funders	Funder number
Norton Simon Fund
National Institutes of Health	R01 CA69370
U.S. Department of Energy	DE-FC03-87-ER60615
University of California, Los Angeles
Whitaker Foundation	J100193
Ahmanson Foundation

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Cherry, S. R., Shao, Y., Silverman, R. W., Meadors, K., Siegel, S., Chatziioannou, A., Young, J. W., Jones, W. F., Moyers, J. C., Newport, D., Boutefnouchet, A., Farquhar, T. H., Andreaco, M., Paulus, M. J., Binkley, D. M., Nutt, R., & Phelps, M. E. (1997). MicroPET: A high resolution PET scanner for imaging small animals. IEEE Transactions on Nuclear Science, 44(3 PART 2), 1161-1166. https://doi.org/10.1109/23.596981

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title = "MicroPET: A high resolution PET scanner for imaging small animals",

abstract = "MicroPET is a high resolution positron emission tomography (PET) scanner designed for imaging small laboratory animals. It consists of a ring of 30 positionsensitive scintillation detectors, each with an 8 x 8 array of small lutetium oxyorthosilicate (LSO) crystals coupled via optical fibers to a multi-channel photomultiplier tube. The detectors have an intrinsic resolution averaging 1.68 mm, an energy resolution between 15 and 25% and 2.4 ns timing resolution at 511 keV. The detector ring diameter of microPET is 17.2 cm with an imaging field of view of 112 mm transaxially by 18 mm axially. The scanner has no septa and operates exclusively in 3D mode. Reconstructed image resolution 1 cm from the center of the scanner is 2.0 mm and virtually isotropic, yielding a volume resolution of 8 mm3. For comparison, the volume resolution of state-of-the-art clinical PET systems is in the range of 50 - 75 mnA Initial images of phantoms have been acquired and are reported. A computer controlled bed is under construction and will incorporate a small wobble motion to improve spatial sampling. This is projected to further enhance spatial resolution. MicroPET is the first PET scanner to incorporate the new scintillator LSO and to our knowledge is the highest resolution multi-ring PET scanner currently in existence.",

author = "Cherry, {S. R.} and Y. Shao and Silverman, {R. W.} and K. Meadors and S. Siegel and A. Chatziioannou and Young, {J. W.} and Jones, {W. F.} and Moyers, {J. C.} and D. Newport and A. Boutefnouchet and Farquhar, {T. H.} and M. Andreaco and Paulus, {M. J.} and Binkley, {D. M.} and R. Nutt and Phelps, {M. E.}",

year = "1997",

doi = "10.1109/23.596981",

language = "English",

volume = "44",

pages = "1161--1166",

journal = "IEEE Transactions on Nuclear Science",

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Cherry, SR, Shao, Y, Silverman, RW, Meadors, K, Siegel, S, Chatziioannou, A, Young, JW, Jones, WF, Moyers, JC, Newport, D, Boutefnouchet, A, Farquhar, TH, Andreaco, M, Paulus, MJ, Binkley, DM, Nutt, R & Phelps, ME 1997, 'MicroPET: A high resolution PET scanner for imaging small animals', IEEE Transactions on Nuclear Science, vol. 44, no. 3 PART 2, pp. 1161-1166. https://doi.org/10.1109/23.596981

TY - JOUR

T1 - MicroPET

T2 - A high resolution PET scanner for imaging small animals

AU - Cherry, S. R.

AU - Shao, Y.

AU - Silverman, R. W.

AU - Meadors, K.

AU - Siegel, S.

AU - Chatziioannou, A.

AU - Young, J. W.

AU - Jones, W. F.

AU - Moyers, J. C.

AU - Newport, D.

AU - Boutefnouchet, A.

AU - Farquhar, T. H.

AU - Andreaco, M.

AU - Paulus, M. J.

AU - Binkley, D. M.

AU - Nutt, R.

AU - Phelps, M. E.

PY - 1997

Y1 - 1997

N2 - MicroPET is a high resolution positron emission tomography (PET) scanner designed for imaging small laboratory animals. It consists of a ring of 30 positionsensitive scintillation detectors, each with an 8 x 8 array of small lutetium oxyorthosilicate (LSO) crystals coupled via optical fibers to a multi-channel photomultiplier tube. The detectors have an intrinsic resolution averaging 1.68 mm, an energy resolution between 15 and 25% and 2.4 ns timing resolution at 511 keV. The detector ring diameter of microPET is 17.2 cm with an imaging field of view of 112 mm transaxially by 18 mm axially. The scanner has no septa and operates exclusively in 3D mode. Reconstructed image resolution 1 cm from the center of the scanner is 2.0 mm and virtually isotropic, yielding a volume resolution of 8 mm3. For comparison, the volume resolution of state-of-the-art clinical PET systems is in the range of 50 - 75 mnA Initial images of phantoms have been acquired and are reported. A computer controlled bed is under construction and will incorporate a small wobble motion to improve spatial sampling. This is projected to further enhance spatial resolution. MicroPET is the first PET scanner to incorporate the new scintillator LSO and to our knowledge is the highest resolution multi-ring PET scanner currently in existence.

AB - MicroPET is a high resolution positron emission tomography (PET) scanner designed for imaging small laboratory animals. It consists of a ring of 30 positionsensitive scintillation detectors, each with an 8 x 8 array of small lutetium oxyorthosilicate (LSO) crystals coupled via optical fibers to a multi-channel photomultiplier tube. The detectors have an intrinsic resolution averaging 1.68 mm, an energy resolution between 15 and 25% and 2.4 ns timing resolution at 511 keV. The detector ring diameter of microPET is 17.2 cm with an imaging field of view of 112 mm transaxially by 18 mm axially. The scanner has no septa and operates exclusively in 3D mode. Reconstructed image resolution 1 cm from the center of the scanner is 2.0 mm and virtually isotropic, yielding a volume resolution of 8 mm3. For comparison, the volume resolution of state-of-the-art clinical PET systems is in the range of 50 - 75 mnA Initial images of phantoms have been acquired and are reported. A computer controlled bed is under construction and will incorporate a small wobble motion to improve spatial sampling. This is projected to further enhance spatial resolution. MicroPET is the first PET scanner to incorporate the new scintillator LSO and to our knowledge is the highest resolution multi-ring PET scanner currently in existence.

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VL - 44

SP - 1161

EP - 1166

JO - IEEE Transactions on Nuclear Science

JF - IEEE Transactions on Nuclear Science

IS - 3 PART 2

ER -

MicroPET: A high resolution PET scanner for imaging small animals

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